RGD Reference Report - SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat. - Rat Genome Database

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SCP2: a major protein component of the axial elements of synaptonemal complexes of the rat.

Authors: Offenberg, HH  Schalk, JA  Meuwissen, RL  Van Aalderen, M  Kester, HA  Dietrich, AJ  Heyting, C 
Citation: Offenberg HH, etal., Nucleic Acids Res 1998 Jun 1;26(11):2572-9.
RGD ID: 69387
Web Url: http://www.oup.co.uk/nar/Volume_26/Issue_11/gkb467_gml.abs.html
Pubmed: PMID:9592139   (View Abstract at PubMed)
PMCID: PMC147596   (View Article at PubMed Central)

In the axial elements of synaptonemal complexes (SCs) of the rat, major protein components have been identified, with relative electrophoretic mobilities (M rs) of 30 000-33 000 and 190 000. Using monoclonal anti-SC antibodies, we isolated cDNA fragments which encode the 190 000 M r component of rat SCs. The translation product predicted from the nucleotide sequence of the cDNA, called SCP2 (for synaptonemal complex protein 2), is a basic protein (pI = 8.0) with a molecular mass of 173 kDa. At the C-terminus, a stretch of approximately 50 amino acid residues is predicted to be capable of forming coiled-coil structures. SCP2 contains two clusters of S/T-P motifs, which are common in DNA-binding proteins. These clusters flank the central, most basic part of the protein (pI = 9.5). Three of the S/T-P motifs are potential target sites for p34(cdc2) protein kinase. In addition, SCP2 has eight potential cAMP/cGMP-dependent protein kinase target sites. The gene encoding SCP2 is transcribed specifically in the testis, in meiotic prophase cells. At the amino acid sequence and secondary structural level, SCP2 shows some similarity to the Red1 protein, which is involved in meiotic recombination and the assembly of axial elements of SCs in yeast. We speculate that SCP2 is a DNA-binding protein involved in the structural organization of meiotic prophase chromosomes.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Sycp2Ratsynaptonemal complex  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sycp2  (synaptonemal complex protein 2)

Objects referenced in this article
Gene SYCP2 synaptonemal complex protein 2 Homo sapiens

Additional Information