RGD Reference Report - Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. - Rat Genome Database

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Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains.

Authors: Saad, Y  Garrett, MR  Rapp, JP 
Citation: Saad Y, etal., Physiol Genomics 2001 Jan 19;4(3):201-14.
RGD ID: 68885
Pubmed: PMID:11160999   (View Abstract at PubMed)

A series of congenic strains were constructed in which segments of chromosome (chr) 1 from Lewis (LEW) rats were introgressed into the Dahl salt-sensitive (S) strain. Three blood pressure quantitative trait loci (QTL) were defined. Two of these (QTL 1a and QTL 1b) were closely linked in the region between 1q31 and 1q35. The third blood pressure QTL (QTL region 2) was close to the centromere between 1p11 and 1q12, which includes the candidate gene Slc9a3 for sodium/hydrogen exchange. The blood pressure QTL 1a and QTL 1b defined here overlap significantly with QTL for disease phenotypes of renal failure, stroke, ventricular mass, and salt susceptibility defined in other rat strains, implying that these disease phenotypes and our blood pressure phenotype have causes in common. QTL 1b also corresponded approximately with a blood pressure QTL described on human chr 15. The QTL region 2 corresponded approximately with blood pressure QTL described on mouse chr 10 and human chr 6.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp93Rathypertension  IDA  RGD 
Bp94Rathypertension  IDA  RGD 
Bp95Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS.LEW-(D1Mco36-D1Rat49)/JrRatdecreased heart weight  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Rat35-D1Rat49)/JrRatdecreased heart weight  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Mco36-D1Rat49)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Mco38-D1Rat49)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Rat196-D1Mco36)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Rat196-D1Rat49)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Rat35-D1Rat49)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Uia2-D1Rat49)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Uia8-D1Mco38)/JrRatdecreased systemic arterial systolic blood pressure  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D1Mco87-D1Rat71)/JrRatincreased heart weight  IAGPcontrolled sodium content dietcompared to SS/JrRGD 
Bp93Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp94Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp95Ratincreased systemic arterial blood pressure  QTM  RGD 

Objects referenced in this article
QTL Bp27 Blood pressure QTL 27 Rattus norvegicus
QTL Bp30 Blood pressure QTL 30 Rattus norvegicus
Strain SS.LEW-(D1Rat196-D1Mgh7)/Jr null Rattus norvegicus
Strain SS.LEW-(D1Rat211-D1Rat18)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Rat42-D1Wox10)/Jr null Rattus norvegicus
Strain SS.LEW-(D1Uia8-D1Rat124)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Uia8-D1Rat18)/Mco null Rattus norvegicus
Strain SS.LEW-(D1Uia8-D1Rat213)/Mco null Rattus norvegicus
Strain SS.LEW-(D5Uia4-D5Mco10)/Jr null Rattus norvegicus

Additional Information