RGD Reference Report - Cognitive impairment and changes of neuronal plasticity in rats of chronic cerebral hypoperfusion associated with cerebral arteriovenous malformations.

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Cognitive impairment and changes of neuronal plasticity in rats of chronic cerebral hypoperfusion associated with cerebral arteriovenous malformations.
Authors:	Hai, J Su, SH Lin, Q Zhang, L Wan, JF Li, H Chen, YY Lu, Y
Citation:	Hai J, etal., Acta Neurol Belg. 2010 Jun;110(2):180-5.
RGD ID:	6483324
Pubmed:	PMID:20873448 (View Abstract at PubMed)
A new rat model associated with cerebral arteriovenous malformations (AVMs) was developed to study the effect of chronic cerebral hypoperfusion on cognitive function and neuronal plasticity in rats. Aged-matched animals comprised a control group. Three months after surgery, Morris water waze test was performed to evaluate the cognitive function in rats. Neuronal plasticity was assessed by measuring the protein expression of MAP-2, GAP-43 and synaptophysin in the hippocampal regions of rats with immunohistochemistry and western blotting. The average time of escape latency was significantly longer in the model rats than that in the control rats, and both the time spent in the platform quadrant and the frequency of original platform crossing during space probe trials were less than those in the control animals. The expression levels of MAP-2 and synaptophysin protein in hippocampal areas in the model rats were less than those in the control rats. However there was no difference on the GAP-43 expression between the two groups. These data suggest that chronic cerebral hypoperfusion associated with AVMs could lead to cognitive impairment in rats, which may be partially explained by reduced expression of MAP-2 and synaptophysin at the protein level in the hippocampal area.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
MAP2	Human	arteriovenous malformation		ISO	Map2 (Rattus norvegicus)	protein:decreased expression:hippocampus	RGD
Map2	Rat	arteriovenous malformation		IEP		protein:decreased expression:hippocampus	RGD
Map2	Mouse	arteriovenous malformation		ISO	Map2 (Rattus norvegicus)	protein:decreased expression:hippocampus	RGD

Objects Annotated

Genes (Rattus norvegicus)

Map2 (microtubule-associated protein 2)

Genes (Mus musculus)

Map2 (microtubule-associated protein 2)

Genes (Homo sapiens)

MAP2 (microtubule associated protein 2)

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Cognitive impairment and changes of neuronal plasticity in rats of chronic cerebral hypoperfusion associated with cerebral arteriovenous malformations.