RGD Reference Report - Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats. - Rat Genome Database

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Mapping of two genetic loci, Ten-1 and Ten-2, associated with thymus enlargement in BUF/Mna rats.

Authors: Murakumo, Y  Takahashi, M  Sharma, N  Arakawa, A  Saito, M  Amo, H  Matsuyama, M 
Citation: Murakumo Y, etal., Mamm Genome 1996 Jul;7(7):505-8.
RGD ID: 634747
Pubmed: PMID:8672128   (View Abstract at PubMed)

The thymoma-prone BUF/Mna rat is a useful model for human thymoma. Thymoma develops spontaneously in these rats at an incidence of nearly 100%. At pre-thymoma age, BUF/Mna rats have extremely large thymuses when compared with those of rats of the other strains, suggesting the presence of genes that regulate the thymus enlargement. We performed linkage study to identify the genetic loci associated with thymus enlargement in inverted question mark(WKY/NCrj x BUF/Mna) F1 x BUF/Mna inverted question mark backcross rats. Linkage study showed the significant associations between thymus size and markers on Chromosomes (Chrs) 1 and 13, suggesting the presence of two genes, Ten-1 and Ten-2, which regulate the thymus enlargement. Ten-1 was located between myosin light chain, muscle 2 (MYL2) and D1Mgh11 loci on Chr 1, and Ten-2 was located between synaptotagmin II (SYT2) and D13N2 loci on Chr 13.




Related Phenotype Data for Reference

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer data
BUF/Mna WKY/NCrlCrlj

Objects Annotated

QTLs
Thym2  (Thymus enlargement QTL 2)

Strains
BUF/Mna  (NA)
WKY/NCrlCrlj  (NA)

Objects referenced in this article
Strain ACI.BUF-Ten1/Mna null Rattus norvegicus
Strain ACI.BUF-Ten2/Mna null Rattus norvegicus
QTL Thym1 Thymus enlargement QTL 1 Rattus norvegicus

Additional Information