RGD Reference Report - Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat. - Rat Genome Database

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Five quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue cancer in the rat.

Authors: Tanuma, JI  Fujii, K  Hirano, M  Matsuuchi, H  Shisa, H  Hiai, H  Kitano, M 
Citation: Tanuma JI, etal., Jpn J Cancer Res 2001 Jun;92(6):610-6.
RGD ID: 634723
Pubmed: PMID:11429048   (View Abstract at PubMed)
PMCID: PMC5926756   (View Article at PubMed Central)

In our previous study, Dark-Agouti (DA) rats were found to be highly susceptible to 4-nitroquinoline 1-oxide (4NQO)-induced tongue carcinoma (TC), whereas Wistar / Furth (WF) rats were barely susceptible. Interval mapping analysis of reciprocal backcross rats showed two quantitative trait loci (QTL) on rat chromosomes (RNO) 1 and 19. In the present study, a composite interval mapping analysis was applied to 4NQO-induced TC in 130 (DA x WF) F2 rats, demonstrating five independent QTL, Tongue squamous cell carcinoma 1 - 5 (Tscc1 - 5), responsible for phenotypic differences in the size and number of TCs in the two strains. Two of these QTL were mapped on RNO1, and the others were mapped on RNO4, 14, and 19. The DA allele at these loci consistently yielded semidominant susceptibility to TC. Out of the five loci detected in this F2 generation, Tscc1 and 2 were identical to Stc1 and Rtc1 described in our previous study, but the other three were novel. We propose a new nomenclature consistent with their function. Genome-wide screening of the F2 progeny also suggested the presence of three additional QTL on RNO5, 6, and 10. The possible roles of these loci in tongue carcinogenesis are discussed.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tcas10RatTongue Neoplasms  IAGP  RGD 
Tcas5RatTongue Neoplasms  IDA  RGD 
Tcas6RatTongue Neoplasms  IDA  RGD 
Tcas8RatTongue Neoplasms  IAGP  RGD 
Tcas9RatTongue Neoplasms  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tcas10Ratincreased tongue tumor incidence  IDA  RGD 
Tcas5Ratincreased tongue tumor incidence  IDA  RGD 
Tcas6Ratincreased tongue tumor incidence  IDA  RGD 
Tcas8Ratincreased tongue tumor incidence  IDA  RGD 
Tcas9Ratincreased tongue tumor incidence  IDA  RGD 
Objects Annotated

QTLs
Tcas10  (Tongue tumor susceptibility QTL 10)
Tcas2  (Tongue tumor susceptibility QTL 2)
Tcas3  (Tongue tumor susceptibility QTL 3)
Tcas4  (Tongue tumor susceptibility QTL 4)
Tcas5  (Tongue tumor susceptibility QTL 5)
Tcas6  (Tongue tumor susceptibility QTL 6)
Tcas8  (Tongue tumor susceptibility QTL 8)
Tcas9  (Tongue tumor susceptibility QTL 9)

Strains
DA  (DA)
WF  (Wistar Furth)

Objects referenced in this article
Strain DA.WF-(D1Mgh21-D1Mgh10)(D4Mit11-Nos3)(D1Mit1-D1Mit3)/Kop null Rattus norvegicus
Strain DA.WF-(D1Mgh21-D1Mgh10)(D4Mit11-Nos3)/Kop null Rattus norvegicus
Strain DA.WF-(D1Mit1-D1Mit3)/Kop null Rattus norvegicus
Strain WF.DA-(D19Mit1-D19Mit6)/Kop null Rattus norvegicus

Additional Information