RGD Reference Report - Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat. - Rat Genome Database

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Differential hormonal regulation of carbonyl reductase activities in liver and kidney microsomes of rat.

Authors: Imamura, Y  Takada, H  Kamizono, R  Otagiri, M 
Citation: Imamura Y, etal., Xenobiotica 2002 Sep;32(9):729-37.
RGD ID: 634703
Pubmed: PMID:12396270   (View Abstract at PubMed)
DOI: DOI:10.1080/00498250210144848   (Journal Full-text)

1. In the male rat, hepatic microsomal carbonyl reductase (CR) activity decreased by testectomy (Tx) was restored to the control level by the treatment with testosterone propionate (TP), even though the enzyme activity decreased by hypophysectomy (Hx) was not increased by the treatment with TP. On the other hand, renal microsomal CR activities decreased by Tx and Hx were markedly increased by the treatment with TP. 2. The treatment with TP had no effect on the CR activity in liver microsomes of the ovariectomized or hypophysectomized female rat. On the other hand, the CR activities in kidney microsomes of the ovariectomized and hypophysectomized female rat were significantly increased by the treatment with TP. 3. The results indicate that in rat programmed by neonatal androgens, the hepatic microsomal CR activity is regulated indirectly by androgens through the hypothalamus-pituitary system, whereas the hormonal regulation of the renal microsomal CR activity is not via the pituitary. We conclude that the regulatory mechanism of the CR activity in liver microsomes is distinguishable from that in kidney microsomes.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cbr1Ratcarbonyl reductase (NADPH) activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cbr1  (carbonyl reductase 1)


Additional Information