RGD Reference Report - AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. - Rat Genome Database

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AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats.

Authors: Kuja-Panula, J  Kiiltomaki, M  Yamashiro, T  Rouhiainen, A  Rauvala, H 
Citation: Kuja-Panula J, etal., J Cell Biol 2003 Mar 17;160(6):963-73.
RGD ID: 634626
Pubmed: PMID:12629050   (View Abstract at PubMed)
PMCID: PMC2173769   (View Article at PubMed Central)
DOI: DOI:10.1083/jcb.200209074   (Journal Full-text)

Ordered differential display identified a novel sequence induced in neurons by the neurite-promoting protein amphoterin. We named this gene amphoterin-induced gene and ORF (AMIGO), and also cloned two other novel genes homologous to AMIGO (AMIGO2 and AMIGO3). Together, these three AMIGOs form a novel family of genes coding for type I transmembrane proteins which contain a signal sequence for secretion and a transmembrane domain. The deduced extracellular parts of the AMIGOs contain six leucine-rich repeats (LRRs) flanked by cysteine-rich LRR NH2- and COOH-terminal domains and by one immunoglobulin domain close to the transmembrane region. A substrate-bound form of the recombinant AMIGO ectodomain promoted prominent neurite extension in hippocampal neurons, and in solution, the same AMIGO ectodomain inhibited fasciculation of neurites. A homophilic and heterophilic binding mechanism is shown between the members of the AMIGO family. Our results suggest that the members of the AMIGO protein family are novel cell adhesion molecules among which AMIGO is specifically expressed on fiber tracts of neuronal tissues and participates in their formation.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Amigo1Rataxonal fasciculation involved_inIDA PMID:12629050UniProt 
Amigo1Rataxonogenesis  IDA  RGD 
Amigo1Ratcell adhesion  TAS  RGD 
Amigo1Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q80ZD5PMID:12629050UniProt 
Amigo1Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q7TNJ4PMID:12629050UniProt 
Amigo2Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q80ZD7PMID:12629050UniProt 
Amigo2Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q80ZD5PMID:12629050UniProt 
Amigo3Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q7TNJ4PMID:12629050UniProt 
Amigo3Ratheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules involved_inIPIUniProtKB:Q80ZD7PMID:12629050UniProt 
Amigo1Rathomophilic cell adhesion via plasma membrane adhesion molecules involved_inIPIUniProtKB:Q80ZD7PMID:12629050UniProt 
Amigo2Rathomophilic cell adhesion via plasma membrane adhesion molecules involved_inIPIUniProtKB:Q7TNJ4PMID:12629050UniProt 
Amigo1Ratmyelination involved_inIEP PMID:12629050UniProt 
Amigo3Ratnervous system development  IDA  RGD 
Amigo1Ratneuron projection fasciculation  IDA  RGD 
Amigo1Ratpositive regulation of axonogenesis involved_inIDA PMID:12629050UniProt 
Amigo1Ratpositive regulation of neuron projection development  IDA  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Amigo3Ratmembrane located_inNAS PMID:12629050UniProt 
Amigo1Ratneuronal cell body  IDAMMO:0000538 RGD 
Amigo1Ratpericellular basket  IDAMMO:0000538 RGD 
Amigo1Ratplasma membrane located_inNAS PMID:12629050UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Amigo1Ratprotein binding enablesIPIUniProtKB:Q7TNJ4PMID:12629050UniProt 
Amigo1Ratprotein binding  IPIRGD:727911|RGD:631413 RGD 
Amigo1Ratprotein binding enablesIPIUniProtKB:Q80ZD7PMID:12629050UniProt 
Amigo1Ratprotein binding enablesIPIUniProtKB:Q80ZD5PMID:12629050UniProt 
Amigo2Ratprotein binding  IPIRGD:1303079|RGD:631413 RGD 
Amigo3Ratprotein binding enablesIPIUniProtKB:Q7TNJ4PMID:12629050UniProt 
Amigo3Ratprotein binding enablesIPIUniProtKB:Q80ZD7PMID:12629050UniProt 
Amigo3Ratprotein binding  IPIRGD:1303079|RGD:727911 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Amigo1  (adhesion molecule with Ig like domain 1)
Amigo2  (adhesion molecule with Ig like domain 2)
Amigo3  (adhesion molecule with Ig like domain 3)

Objects referenced in this article
Gene Amigo1 adhesion molecule with Ig like domain 1 Mus musculus
Gene Amigo2 adhesion molecule with Ig like domain 2 Mus musculus
Gene Amigo3 adhesion molecule with Ig like domain 3 Mus musculus

Additional Information