RGD Reference Report - Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. - Rat Genome Database

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Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet.

Authors: Garrett, MR  Dene, H  Rapp, JP 
Citation: Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
RGD ID: 634617
Pubmed: PMID:12707388   (View Abstract at PubMed)

The Dahl salt-sensitive hypertensive (S) rat develops albuminuria early in life even on a low-salt diet. In contrast, the spontaneously hypertensive rat (SHR) is highly resistant to developing albuminuria despite elevated BP. An F(1) hybrid of S and SHR showed a low urinary albumin excretion (UAE) and low urinary protein excretion (UPE) similar to SHR, i.e., SHR was dominant. A genetic analysis was carried out on a large population (n = 276) obtained by backcrossing F(1) rats to the recessive S strain; the population was fed a low-salt diet. Genome scans done at 8, 12, and 16 wk of age yielded ten quantitative trait loci (QTL) for UAE and/or UPE with variable time-course patterns on nine rat chromosomes (RNO), i.e., RNO1, RNO2, RNO6, RNO8, RNO9, RNO10, RNO11, RNO13, and RNO19. There were two UPE QTL on RNO6. At most of the UAE and/or UPE QTL, the S allele was associated with increased excretion, except for one of the QTL on RNO6 and the QTL on RNO11, where the S allele caused decreased excretion. Only the UAE and UPE QTL on RNO10 co-localized with a BP QTL. The S allele on RNO10 caused higher BP and higher UAE. Two additional BP QTL were detected on RNO1 and RNO6. Most of the UAE and UPE QTL co-localized with QTL for kidney lesions characteristic of S rats. Multiple interactions were observed for UAE, many of which involved RNO2. In summary, UAE is highly polygenic and the majority of the QTL altering UAE do not co-localize with QTL for BP as evaluated by tail-cuff measurements of BP.

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Objects Annotated

Cm16  (Cardiac mass QTL 16)
Cm17  (Cardiac mass QTL 17)
Cm18  (Cardiac mass QTL 18)
Cm19  (Cardiac mass QTL 19)
Cm20  (Cardiac mass QTL 20)
Cm21  (Cardiac mass QTL 21)
Kidm1  (Kidney mass QTL 1)
Kidm2  (Kidney mass QTL 2)
Kidm3  (Kidney mass QTL 3)
Pur2  (Proteinuria QTL 2)
Uae10  (Urinary albumin excretion QTL 10)
Uae11  (Urinary albumin excretion QTL 11)
Uae12  (Urinary albumin excretion QTL 12)
Uae13  (Urinary albumin excretion QTL 13)
Uae5  (Urinary albumin excretion QTL 5)
Uae6  (Urinary albumin excretion QTL 6)
Uae7  (Urinary albumin excretion QTL 7)
Uae8  (Urinary albumin excretion QTL 8)
Uae9  (Urinary albumin excretion QTL 9)

SHR/NHsd  (NA)
SS/Jr  (Salt Sensitive)
SS/JrTol  (Dahl salt-sensitive (SS/Jr) rats)

Objects referenced in this article
Strain F344/NHsd F344/NHsd Rattus norvegicus

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