RGD Reference Report - Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. - Rat Genome Database

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Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.

Authors: Wang, Y  Okamoto, M  Schmitz, F  Hofmann, K  Sudhof, TC 
Citation: Wang Y, etal., Nature 1997 Aug 7;388(6642):593-8.
RGD ID: 633897
Pubmed: PMID:9252191   (View Abstract at PubMed)
DOI: DOI:10.1038/41580   (Journal Full-text)

Rab3 is a neuronal GTP-binding protein that regulates fusion of synaptic vesicles and is essential for long-term potentiation of hippocampal mossy fibre synapses. More than thirty Rab GTP-binding proteins are known to function in diverse membrane transport pathways, although their mechanisms of action are unclear. We have now identified a putative Rab3-effector protein called Rim. Rim is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. It binds only to GTP (but not to GDP)-complexed Rab3, and interacts with no other Rab protein tested. There is enrichment of Rab3 and Rim in neurons, where they have complementary distributions. Rab3 is found only on synaptic vesicles, whereas Rim is localized to presynaptic active zones in conventional synapses, and to presynaptic ribbons in ribbon synapses. Transfection of PC12 cells with the amino-terminal domains of Rim greatly enhances regulated exocytosis in a Rab3-dependent manner. We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rims1Ratpositive regulation of synaptic vesicle fusion to presynaptic active zone membrane involved_inNAS PMID:9252191UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rims2Ratphotoreceptor ribbon synapse is_active_inIDA PMID:9252191SynGO 
Rims1Ratpresynaptic active zone cytoplasmic component is_active_inIDA PMID:9252191SynGO 
Rims2Ratpresynaptic active zone cytoplasmic component is_active_inIDA PMID:9252191SynGO 
Rims1Ratpresynaptic membrane located_inIDA PMID:9252191UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Rims1  (regulating synaptic membrane exocytosis 1)
Rims2  (regulating synaptic membrane exocytosis 2)


Additional Information