RGD Reference Report - mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains. - Rat Genome Database

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mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains.

Authors: Goldberg, M  Peshkovsky, C  Shifteh, A  Al-Awqati, Q 
Citation: Goldberg M, etal., J Biol Chem 2000 Aug 11;275(32):24622-9.
RGD ID: 633361
Pubmed: PMID:10801787   (View Abstract at PubMed)
DOI: DOI:10.1074/jbc.M000234200   (Journal Full-text)

Branching morphogenesis is a central event during the development of kidneys, lungs, and other organs. We previously generated a monoclonal antibody, 3D2-E9, that inhibited branching morphogenesis and caused widespread apoptosis. We now report the purification of its antigen and cloning of its full-length cDNA. Its cDNA encodes an integral membrane protein that contains four cadherin-like ectodomains and a thrice tandemly repeated region enriched in threonine, serine, and proline, similar to those of mucins. We thus term this protein mu-protocadherin, reflecting the hybrid nature of its extracellular region. mu-Protocadherin is expressed in two forms that are developmentally regulated, with the shorter isoform lacking the mucin-like repeats. Expression of the long isoform in heterologous cells results in adhesion of the expressing cells, suggesting that it is a new cell adhesion molecule. mu-Protocadherin contains both N and O glycosylations. It is expressed at lateral and basal surfaces of epithelia during kidney and lung development and is located in coated pits. Colocalization of mu-protocadherin with beta-catenin was noted primarily at the junction of the lateral and basal membrane. The cytoplasmic domain contains four proline-rich regions, similar to SH3 binding regions. Thus, it is likely that adhesive interactions mediated by mu-protocadherin induce signaling events that regulate branching morphogenesis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdhr5Ratcell adhesion involved_inIDA PMID:10801787UniProt 
Cdhr5Ratcell adhesion  IMP  RGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdhr5Ratclathrin-coated pit  IDA  RGD 
Cdhr5Ratmembrane located_inNAS PMID:10801787UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdhr5Ratcalcium ion binding enablesIDA PMID:10801787UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Cdhr5  (cadherin-related family member 5)


Additional Information