RGD Reference Report - Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat. - Rat Genome Database

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Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat.

Authors: Pravenec, M  Kren, V  Krenova, D  Zidek, V  Simakova, M  Musilova, A  Vorlicek, J  Lezin, ES  Kurtz, TW 
Citation: Pravenec M, etal., Physiol Res 2003;52(3):285-9.
RGD ID: 631851
Pubmed: PMID:12790759   (View Abstract at PubMed)

Total genome scans of genetically segregating populations derived from spontaneously hypertensive rats (SHR) and other rat models of essential hypertension suggested a presence of quantitative trait loci (QTL) regulating blood pressure on multiple chromosomes, including chromosome 5. The objective of the current study was to test directly a hypothesis that chromosome 5 of the SHR carries a blood pressure regulatory QTL. A new congenic strain was derived by replacing a segment of chromosome 5 in the SHR/Ola between the D5Wox20 and D5Rat63 markers with the corresponding chromosome segment from the normotensive Brown Norway (BN/Crl) rat. Arterial pressures were directly monitored in conscious, unrestrained rats by radiotelemetry. The transfer of a segment of chromosome 5 from the BN strain onto the SHR genetic background was associated with a significant decrease of systolic blood pressure, that was accompanied by amelioration of renal hypertrophy. The heart rates were not significantly different in the SHR compared to SHR chromosome 5 congenic strain. The findings of the current study demonstrate that gene(s) with major effects on blood pressure and renal mass exist in the differential segment of chromosome 5 trapped within the new SHR.BN congenic strain.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp139Rathypertension  IAGP  RGD 
SHR/OlaIpcvRathypertension MODEL: spontaneousIAGP compared to SHR.BN-(D5Wox12-D5Wox20)/Ipcv strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHR.BN-(D5Wox12-D5Wox20)/IpcvRatdecreased kidney weight  IAGP compared to SHR/OlaIpcv strainRGD 
SHR.BN-(D5Wox12-D5Wox20)/IpcvRatdecreased systemic arterial systolic blood pressure  IAGP compared to SHR/OlaIpcv strainRGD 
SHR.BN-(D5Wox12-D5Wox20)/IpcvRatincreased body weight  IAGP compared to SHR/OlaIpcv strainRGD 
Bp139Ratincreased systemic arterial blood pressure  IAGP  RGD 

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Objects Annotated

QTLs
Bp139  (Blood pressure QTL 139)


Additional Information