RGD Reference Report - Identification of female-specific QTLs affecting an emotionality-related behavior in rats. - Rat Genome Database

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Identification of female-specific QTLs affecting an emotionality-related behavior in rats.

Authors: Ramos, A  Moisan, MP  Chaouloff, F  Mormede, C  Mormede, P 
Citation: Ramos A, etal., Mol Psychiatry 1999 Sep;4(5):453-62.
RGD ID: 631324
Pubmed: PMID:10523818   (View Abstract at PubMed)

The influence of genetic factors on psychological traits and disorders has been repeatedly demonstrated; however, the molecular mechanisms underlying such an influence remain largely unknown. Anxiety-related disorders constitute the most common class of mental disorder in humans, with women being diagnosed far more frequently than men. A better understanding of the genetic and gender-related mechanisms mediating anxiety traits should enable the development of more rational methods for preventing and treating anxiety disorders. In this study we have aimed to identify, for the first time, quantitative trait loci (QTL) influencing anxiety/emotionality-related traits in rats. To this end, two strains-Lewis (LEW) and Spontaneously Hypertensive Rats (SHR)-that differ for several behavioral measures of anxiety/emotionality were intercrossed. A QTL analysis of the F2 population revealed suggestive loci for various traits, including behaviors in the elevated plus-maze and blood pressure. In addition, one major QTL explaining 50.4% of the total variance (LOD = 7.22) was identified on chromosome 4 for the locomotion in the central and aversive area of the open field. Two other relevant QTLs have been recently mapped near this chromosomic region in the rat, which also harbors Tac1r, the gene encoding for the substance P receptor. Our major QTL affected females but not males and its effect depended on the type of cross (LEW or SHR grandmothers). The present results reveal a complex genetic basis underlying emotional behaviors and they confirm the existence of interactions between genetic factors and sex for this kind of trait. Further investigation of the loci identified herein may give clues to the pathophysiology of psychiatric disorders such as anxiety-related ones.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Anxrr16Ratanxiety disorder  IAGP  RGD 
Anxrr17Ratanxiety disorder  IAGP  RGD 
LEW/NIcoCrlfRatanxiety disorder MODEL: spontaneousIAGP sexual_dimorphism and compared to SHR/NIcoCrlf strainRGD 
Bp141Rathypertension  IAGP  RGD 
Bp142Rathypertension  IAGP  RGD 
SHR/NIcoCrlfRathypertension MODEL: spontaneousIAGP compared to LEW/NIcoCrlf strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHR/NIcoCrlfRatabnormal fear/anxiety-related behavior sexual_dimorphismIAGP compared to malesRGD 
SHR/NIcoCrlfRatabnormal fear/anxiety-related behavior  IAGP compared to LEW/NIcoCrlf strainRGD 
Anxrr17Ratdecreased anxiety-related response  IAGP  RGD 
Anxrr16Ratincreased anxiety-related response  IAGP  RGD 
Bp141Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp142Ratincreased systemic arterial blood pressure  IAGP  RGD 
Objects Annotated

QTLs
Anxrr16  (Anxiety related response QTL 16)
Anxrr17  (Anxiety related response QTL 17)
Bp141  (Blood pressure QTL 141)
Bp142  (Blood pressure QTL 142)


Additional Information