RGD Reference Report - X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci. - Rat Genome Database

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X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.

Authors: Agui, T  Miyamoto, T  Tsumagari, T 
Citation: Agui T, etal., Exp Anim 2001 Apr;50(2):147-51.
RGD ID: 631318
Pubmed: PMID:11381618   (View Abstract at PubMed)

The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). Here we report that the LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat, although it is normal with respect to the hts and thid phenotypes. We further performed genetic linkage analysis of X-ray hypersensitivity in the LEA rat. The quantitative trait loci (QTL) linkage analysis revealed that xhs1 but not xhs2 is the locus responsible for X-ray hypersensitivity in the LEA rat.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Xhs3  (X-ray hypersensitivity QTL 3)

Strains
BN/Sea  (BN/Sea)
LEA/Ncu  (NA)

Objects referenced in this article
Strain LEC/Ncu null Rattus norvegicus

Additional Information