RGD Reference Report - Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat. - Rat Genome Database

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Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat.

Authors: Masuyama, T  Fuse, M  Yokoi, N  Shinohara, M  Tsujii, H  Kanazawa, M  Kanazawa, Y  Komeda, K  Taniguchi, K 
Citation: Masuyama T, etal., Biochem Biophys Res Commun 2003 Apr 25;304(1):196-206.
RGD ID: 631173
Pubmed: PMID:12705906   (View Abstract at PubMed)

The Spontaneously Diabetic Torii (SDT) rat has recently been established as a new rat model of nonobese type 2 diabetes. In this study, we characterized diabetic features in SDT rats, and performed quantitative trait locus (QTL) analysis for glucose intolerance using 319 male (BNxSDT)xSDT backcrosses. Male SDT rats exhibited glucose intolerance at 20 weeks, and spontaneously developed diabetes with the incidence of 100% at 38 weeks, and glucose intolerance is well associated with the development of diabetes. The QTL analysis identified three highly significant QTLs (Gisdt1, Gisdt2, and Gisdt3) for glucose intolerance on rat chromosomes 1, 2, and X, respectively. The SDT allele for these QTLs significantly exacerbated glucose intolerance. Furthermore, synergistic interactions among these QTLs were detected. These findings indicate that diabetic features in SDT rats are inherited as polygenic traits and that SDT rats would provide insights into genetics of human type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus MODEL: controlIAGP 631173compared to SDT/JclRGD 
diabetes mellitus MODEL: spontaneousIAGP 631173compared to BN/SeacRGD 
hyperglycemia  IAGP 631173 RGD 
type 2 diabetes mellitus  IDA 631173; 631173; 631173 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperglycemia  IAGP 631173 RGD 
impaired glucose tolerance  QTM 631173; 631173; 631173 RGD 
impaired glucose tolerance  IAGP 631173 RGD 
increased body weight  QTM 631173 RGD 
increased circulating glucose level  IAGP 631173 RGD 

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Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

QTLs
Gluco13  (Glucose level QTL 13)
Gluco14  (Glucose level QTL 14)
Gluco15  (Glucose level QTL 15)

Strains
BN/Seac  (NA)
SDT/Jcl  (NA)

Objects referenced in this article
Strain BN.SDT-Gluco13/Nyo null Rattus norvegicus
Strain BN.SDT-Gluco14/Nyo null Rattus norvegicus
Strain SDT.BN-Gluco13/Nyo null Rattus norvegicus
Strain SDT.BN-Gluco14/Nyo null Rattus norvegicus

Additional Information