RGD Reference Report - Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL. - Rat Genome Database

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Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL.

Authors: Alemayehu, A  Breen, L  Krenova, D  Printz, MP 
Citation: Alemayehu A, etal., Physiol Genomics 2002 Sep 3;10(3):199-210.
RGD ID: 629618
Pubmed: PMID:12209022   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00065.2002   (Journal Full-text)

Evidence exists implying multiple blood pressure quantitative trait loci (QTL) on rat chromosome 2. To examine this possibility, four congenic strains and nine substrains were developed with varying size chromosome segments introgressed from the spontaneously hypertensive rat (SHR/lj) and normotensive Wistar-Kyoto rat (WKY/lj) onto the reciprocal genetic background. Cardiovascular phenotyping was conducted with telemetry over extended periods during standard salt (0.7%) and high-salt (8%) diets. Our results are consistent with at least three independent pressor QTL: transfer of SHR/lj alleles to WKY/lj reveals pressor QTL within D2Rat21-D2Rat27 and D2Mgh10-D2Rat62, whereas transfer of WKY/lj D2Rat161-D2Mit8 to SHR/lj reveals a depressor locus. Our results also suggest a depressor QTL in SHR/lj located within D2Rat161-D2Mgh10. Introgressed WKY/lj segments also reveal a heart rate QTL within D2Rat40-D2Rat50 which abolished salt-induced bradycardia, dependent upon adjoining SHR/lj alleles. This study confirms the presence of multiple blood pressure QTL on chromosome 2. Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hrtrt18RatBradycardia  IAGP  RGD 
Hrtrt18Ratheart disease  IAGP  RGD 
Bp274Rathypertension  QTM  RGD 
Bp275Rathypertension  QTM  RGD 
Bp276Rathypertension  QTM  RGD 
Bp277Rathypertension  QTM  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Bp274  (Blood pressure QTL 274)
Bp275  (Blood pressure QTL 275)
Bp276  (Blood pressure QTL 276)
Bp277  (Blood pressure QTL 277)
Hrtrt18  (Heart rate QTL 18)

Objects referenced in this article
Strain WKY.SHR-(D2Rat161-D2Rat185) null Rattus norvegicus
Strain WKY.SHR-(D2Rat241-D2Rat185) null Rattus norvegicus

Additional Information