RGD Reference Report - Quantitative trait loci influencing hepatic copper in rats. - Rat Genome Database

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Quantitative trait loci influencing hepatic copper in rats.

Authors: De Wolf, ID  Bonne, AC  Fielmich-Bouman, XM  Van Oost, BA  Beynen, AC  Van Zutphen, LF  Van Lith, HA 
Citation: de Wolf ID, etal., Exp Biol Med (Maywood) 2002 Jul;227(7):529-34.
RGD ID: 629572
Pubmed: PMID:12094018   (View Abstract at PubMed)

Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd x BC/CpbU) F(2)-intercross was genetically analyzed. From each F(2) animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0-15.5% of the genetic variance of liver copper content.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
liver disease  IAGP 629572; 629572 RGD 
Wilson disease  IAGP 629572; 629572 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased liver copper level  QTM 629572; 629572 RGD 

Objects Annotated

Hcuc3  (Hepatic copper content QTL 3)
Hcuc4  (Hepatic copper content QTL 4)

BC/CpbU  (NA)
LEW/OlaHsd  (NA)

Objects referenced in this article
QTL Hcuc1 Hepatic copper content QTL 1 Rattus norvegicus

Additional Information