RGD Reference Report - Association of fat cell size and paracrine growth factors in development of hyperplastic obesity. - Rat Genome Database

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Association of fat cell size and paracrine growth factors in development of hyperplastic obesity.

Authors: Marques, BG  Hausman, DB  Martin, RJ 
Citation: Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
RGD ID: 628910
Pubmed: PMID:9843879   (View Abstract at PubMed)

Inguinal, epididymal, and retroperitoneal adipose tissue from lean and obese Zucker rats, 3-15 wk of age, was used to determine the association among adipocyte size distribution, the presence of paracrine growth factors in adipose tissue, and subsequent changes in adipocyte number. For each specific depot and time point, obese rats had a greater percentage of large adipocytes than did lean rats. A positive correlation (P < 0.02) was found in obese rats between the percentage of inguinal and epididymal adipocytes in the 140- to 180-micrometer size range and the ability of conditioned medium prepared from these depots to stimulate cellular proliferation in a bioassay system utilizing preadipocytes from inguinal fat pads of normal rats. Proliferative activity of the conditioned medium from all depots in obese rats was positively correlated (P < 0.01) to subsequent changes in fat cell number. The data presented here for the inguinal and epididymal depot of obese Zucker rats are consistent with the hypothesis that enlarged adipocytes secrete growth factors that induce preadipocyte proliferation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hyperphagia  ISOLepr (Rattus norvegicus)628910; 628910compared to age-matched lean +/fa ratsRGD 
Hyperphagia  IAGP 628910; 628910compared to age-matched lean +/fa ratsRGD 
Hyperphagia MODEL: controlIAGP 628910compared to age-matched obese fa/fa ratsRGD 
Hyperphagia MODEL: spontaneousIAGP 628910compared to age-matched lean +/fa ratsRGD 
obesity  ISOLepr (Rattus norvegicus)628910; 628910compared to age-matched lean +/fa ratsRGD 
obesity  IAGP 628910; 628910compared to age-matched lean +/fa ratsRGD 
obesity MODEL: controlIAGP 628910compared to age-matched obese fa/fa ratsRGD 
obesity MODEL: spontaneousIAGP 628910compared to age-matched lean +/fa ratsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased epididymal fat pad weight  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
increased food intake  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
increased inguinal fat pad weight  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
increased retroperitoneal fat pad weight  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
increased white fat cell number  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
obese  IAGP 628910; 628910; 628910compared to age-matched lean heterozygous +/fa ratsRGD 
Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)
Leprfa  (leptin receptor; fa mutant)

Genes (Mus musculus)
Lepr  (leptin receptor)

Genes (Homo sapiens)
LEPR  (leptin receptor)

Strains
ZUC-Lepr+Ste  (NA)
ZUC-LeprfaSte-/-  (NA)

Objects referenced in this article
Strain ZUC-Leprfa null Rattus norvegicus

Additional Information