RGD Reference Report - Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. - Rat Genome Database

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Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.

Authors: Mullins, JJ  Peters, J  Ganten, D 
Citation: Mullins JJ, etal., Nature 1990 Apr 5;344(6266):541-4.
RGD ID: 628589
Pubmed: PMID:2181319   (View Abstract at PubMed)
DOI: DOI:10.1038/344541a0   (Journal Full-text)

PRIMARY hypertension is a polygenic condition in which blood pressure is enigmatically elevated; it remains a leading cause of cardiovascular disease and death due to cerebral haemorrhage, cardiac failure and kidney disease. The genes for several of the proteins involved in blood pressure homeostasis have been cloned and characterized, including those of the renin-angiotensin system, which plays a central part in blood pressure control. Here we describe the introduction of the mouse Ren-2 renin gene into the genome of the rat and demonstrate that expression of this gene causes severe hypertension. These transgenic animals represent a model for hypertension in which the genetic basis for the disease is known. Further, as the transgenic animals do not overexpress active renin in the kidney and have low levels of active renin in their plasma, they also provide a new model for low-renin hypertension.

Disease Annotations    
hypertension  (IMP)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

SD-Tg(Ren2)27  (NA)

Additional Information