RGD Reference Report - Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. - Rat Genome Database

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Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene.

Authors: Mullins, JJ  Peters, J  Ganten, D 
Citation: Mullins JJ, etal., Nature 1990 Apr 5;344(6266):541-4.
RGD ID: 628589
Pubmed: PMID:2181319   (View Abstract at PubMed)
DOI: DOI:10.1038/344541a0   (Journal Full-text)

PRIMARY hypertension is a polygenic condition in which blood pressure is enigmatically elevated; it remains a leading cause of cardiovascular disease and death due to cerebral haemorrhage, cardiac failure and kidney disease. The genes for several of the proteins involved in blood pressure homeostasis have been cloned and characterized, including those of the renin-angiotensin system, which plays a central part in blood pressure control. Here we describe the introduction of the mouse Ren-2 renin gene into the genome of the rat and demonstrate that expression of this gene causes severe hypertension. These transgenic animals represent a model for hypertension in which the genetic basis for the disease is known. Further, as the transgenic animals do not overexpress active renin in the kidney and have low levels of active renin in their plasma, they also provide a new model for low-renin hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SD-Tg(Ren2)27Rathypertension MODEL: spontaneousIMP compared with SD-Tg(Ren2)27-/-RGD 
SD-Tg(Ren2)27Rathypertension treatmentIMPcaptopril RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SD-Tg(Ren2)27Ratdecreased circulating renin level  IMP  RGD 
SD-Tg(Ren2)27Ratdecreased renin activity  IMP in plasma and kidneyRGD 
SD-Tg(Ren2)27Ratincreased systemic arterial systolic blood pressure  IMP compared to wild-type littermateRGD 
SD-Tg(Ren2)27Ratincreased urine aldosterone level  IMP in maleRGD 
Objects Annotated

SD-Tg(Ren2)27  (NA)

Additional Information