RGD Reference Report - Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains. - Rat Genome Database

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Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains.

Authors: Garrett, MR  Zhang, X  Dukhanina, OI  Deng, AY  Rapp, JP 
Citation: Garrett MR, etal., Hypertension 2001 Oct;38(4):779-85.
RGD ID: 628510
Pubmed: PMID:11641286   (View Abstract at PubMed)

Aquantitative trait locus (QTL) for blood pressure was previously detected on rat chromosome 10 (RNO10) by linkage analysis and confirmed by the construction of congenic strains that encompass large regions of RNO10. In the present study, the rat RNO10 blood pressure QTL was dissected by the further construction of congenic substrains. The original congenic region was shown to contain 2 blood pressure QTLs (QTL 1 and QTL 2) approximately 24 cM apart. These were localized to a <2.6-cM region between markers D10Rat27 and D10Rat24 for QTL 1 and to a <3.2-cM region between D10Rat12 and D10Mco70 for QTL 2. Comparative mapping suggests that the rat RNO10 QTL 2 could be localized very close to a blood pressure QTL described by sib-pair analysis on human chromosome 17, but this is not definitively established because of multiple and complex chromosomal rearrangements between rodents and humans.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp136Rathypertension  IDA  RGD 
Bp137Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SS.LEW-(D10Arb9-D10Got101)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mco38-D10Mco41)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mco38-D10Mgh1)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mit10-D10Mgh1)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mit10-D10Rat24)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Bra1-D10Mit11)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10M11Mit119-D10Mit11)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco15-D10Mit11)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco30-D10Mco31)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco31-D10Mit11)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietas compared to SS/JrRGD 
SS.MNS-(D10Mco62-D10Mco31)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco62-D10Mit1)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Rat13-D10Mit11)/JrRatdecreased heart weight inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Arb9-D10Got101)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mco38-D10Mco41)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mco38-D10Mgh1)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mit10-D10Mgh1)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D10Mit10-D10Rat24)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Bra1-D10Mit11)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10M11Mit119-D10Mit11)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietas compared to SS/JrRGD 
SS.MNS-(D10Mco15-D10Mit11)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco30-D10Mco31)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietas compared to SS/JrRGD 
SS.MNS-(D10Mco31-D10Mit11)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco62-D10Mco31)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Mco62-D10Mit1)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.MNS-(D10Rat13-D10Mit11)/JrRatdecreased systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
Bp136Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp137Ratincreased systemic arterial blood pressure  QTM  RGD 

Objects referenced in this article
QTL Bp303 Blood pressure QTL 303 Rattus norvegicus
Strain SS.LEW-(D10Mit1-D10Mgh1)/Jr null Rattus norvegicus
Strain SS.MNS-(D10Mco70-D10Mit11)/Jr null Rattus norvegicus
Strain SS.MNS-(D10Rat13-D10Rat12)/Jr null Rattus norvegicus
Strain SS.MNS-(D10Rat24-D10Mco31)/Jr null Rattus norvegicus

Additional Information