RGD Reference Report - Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

Authors: Shuto, Y  Shibasaki, T  Otagiri, A  Kuriyama, H  Ohata, H  Tamura, H  Kamegai, J  Sugihara, H  Oikawa, S  Wakabayashi, I 
Citation: Shuto Y, etal., J Clin Invest 2002 Jun;109(11):1429-36.
RGD ID: 625699
Pubmed: PMID:12045256   (View Abstract at PubMed)
PMCID: PMC150991   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI13300   (Journal Full-text)

Growth hormone secretagogues (GHSs) stimulate GH secretion and food intake. GHS receptor (GHS-R) mRNA has been identified mainly in the arcuate nucleus (Arc) and ventromedial nucleus of the hypothalamus and in the pituitary. Ghrelin, an endogenous ligand for GHS-R, has recently been purified from rat stomach. Although ghrelin is also expressed in the hypothalamus, the physiological significance of the ghrelin/GHS-R system is still unknown. We have created transgenic (Tg) rats expressing an antisense GHS-R mRNA under the control of the promoter for tyrosine hydroxylase (TH), thus selectively attenuating GHS-R protein expression in the Arc. Tg rats had lower body weight and less adipose tissue than did control rats. Daily food intake was reduced, and the stimulatory effect of GHS treatment on feeding was abolished in Tg rats. GH secretion and plasma insulin-like growth factor-I levels were reduced in female Tg rats. These results suggest that GHS-R in the Arc is involved in the regulation of GH secretion, food intake, and adiposity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GhsrRatpositive regulation of fatty acid metabolic process  IMP  RGD 
GhsrRatpositive regulation of growth  IMP  RGD 
GhsrRatregulation of feeding behavior  IMP  RGD 
GhsrRatregulation of growth hormone secretion  IMP  RGD 

Molecular Function

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GhsrRatgrowth hormone receptor binding  TAS  RGD 
GhsrRatgrowth hormone secretagogue receptor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghsr  (growth hormone secretagogue receptor)

SD-Tg(Th-Ghsros)  (NA)

Additional Information