RGD Reference Report - Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. - Rat Genome Database

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Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons.

Authors: Yamamoto, H  Lee, CE  Marcus, JN  Williams, TD  Overton, JM  Lopez, ME  Hollenberg, AN  Baggio, L  Saper, CB  Drucker, DJ  Elmquist, JK 
Citation: Yamamoto H, etal., J Clin Invest 2002 Jul;110(1):43-52.
RGD ID: 625448
Pubmed: PMID:12093887   (View Abstract at PubMed)
PMCID: PMC151031   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI15595   (Journal Full-text)

Glucagon-like peptide-1 (GLP-1) released from the gut functions as an incretin that stimulates insulin secretion. GLP-1 is also a brain neuropeptide that controls feeding and drinking behavior and gastric emptying and elicits neuroendocrine responses including development of conditioned taste aversion. Although GLP-1 receptor (GLP-1R) agonists are under development for the treatment of diabetes, GLP-1 administration may increase blood pressure and heart rate in vivo. We report here that centrally and peripherally administered GLP-1R agonists dose-dependently increased blood pressure and heart rate. GLP-1R activation induced c-fos expression in the adrenal medulla and neurons in autonomic control sites in the rat brain, including medullary catecholamine neurons providing input to sympathetic preganglionic neurons. Furthermore, GLP-1R agonists rapidly activated tyrosine hydroxylase transcription in brainstem catecholamine neurons. These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Glp1rRatdiabetes mellitus  TAS  RGD 
Glp1rRathypertension  IDA  RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Glp1rRatneuropeptide signaling pathway  TAS  RGD 
Glp1rRatpositive regulation of blood pressure  IDA  RGD 
Glp1rRatpositive regulation of D-glucose import NOTIDA  RGD 
Glp1rRatpositive regulation of insulin secretion  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Glp1rRatG protein-coupled receptor activity  TAS  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Glp1rRatdecreased circulating glucose level NOTIDA  RGD 
Glp1rRatincreased heart rate  IDA  RGD 
Glp1rRatincreased insulin secretion  IDA  RGD 
Glp1rRatincreased systemic arterial blood pressure  IDA  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Glp1r  (glucagon-like peptide 1 receptor)

Objects referenced in this article
Gene Gcg glucagon Rattus norvegicus

Additional Information