RGD Reference Report - Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection.

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Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection.
Authors:	Olson, FJ Johansson, ME Klinga-Levan, K Bouhours, D Enerback, L Hansson, GC Karlsson, NG
Citation:	Olson FJ, etal., J Biol Chem 2002 Apr 26;277(17):15044-52.
RGD ID:	625392
Pubmed:	PMID:11842091 (View Abstract at PubMed)
DOI:	DOI:10.1074/jbc.M112287200 (Journal Full-text)
Neutral mucin oligosaccharides from the small intestine of control rats and rats infected with the parasite Nippostrongylus brasiliensis were released and analyzed by gas chromatography-mass spectrometry. Infected animals expressed seven blood group A-like structures that were all absent in the control animals. The blood group A nature of these epitopes was confirmed by blood group A reactivity of the prepared mucins, of which Muc2 was one. Transferase assays and Northern blotting on small intestines from infected animals showed that an alpha-N-acetylgalactosaminyltransferase similar to the human blood group A glycosyltransferase had been induced. The expression was a transient event, with a maximum at day 6 of the 13-day-long infection. The rat blood group A glycosyltransferase was cloned, revealing two forms with an amino acid similarity of 95%. Both types had blood group A transferase activity and were probably allelic because none of 12 analyzed inbred strains carried both types. The second type was found in outbred rats and in one inbred strain. First generation offspring of inbred rats of each type were heterozygous, further supporting the allelic hypothesis. The transient induction and the large allelic variation could suggest that glycosyltransferases are part of a dynamic system altering mucins and other glycoconjugates as a protecting mechanism against microbial challenges.

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Biological Process

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Abo3	Rat	defense response to bacterium		IEP			RGD
Abo	Rat	response to nematode		IEP			RGD

Molecular Function

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Abo	Rat	glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity		IDA			RGD
Abo3	Rat	glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity		IDA			RGD

Objects Annotated

Genes (Rattus norvegicus)

Abo (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase)

Abo3 (histo-blood group ABO system transferase 3)

Objects referenced in this article

Gene	Abo	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Mus musculus
Gene	Abo2	histo-blood group ABO system transferase 2	Rattus norvegicus

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Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection.