RGD Reference Report - Genetic dissection of the syndrome X in the rat. - Rat Genome Database

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Genetic dissection of the syndrome X in the rat.

Authors: Kovacs, P  Van den Brandt, J  Kloting, I 
Citation: Kovacs P, etal., Biochem Biophys Res Commun 2000 Mar 24;269(3):660-5.
RGD ID: 619689
Pubmed: PMID:10720472   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2000.2352   (Journal Full-text)

In 1988, Reaven used the term syndrome X to describe a relation between several disorders including hypertension, dyslipidemia, impaired glucose tolerance, obesity, and coronary heart disease. Despite a number of studies dealing with syndrome X, its genetic basis remains poorly understood. Regarding the complexity of this syndrome, it is important to use animal models developing the traits of the disease. Here we show a genetic dissection of syndrome X in the WOKW rat, an animal model of genetically determined syndrome X. We found a major quantitative trait locus (QTL) for glucose metabolism on chromosome 3 and further QTLs influencing obesity and body weight on chromosomes 1 and 5. Genetic determinants of dyslipidemia were mapped to chromosomes 4 and 17. In addition, suggestive linkage for serum insulin was found on chromosome 1 to the region previously shown to be associated with type-1 diabetes mellitus. This is the first study demonstrating independent genetic factors influencing traits of the syndrome X in the rat as well as a possible genetic relationships between syndrome X and diabetes mellitus. Moreover, regarding the close similarities between WOKW rat and human syndrome X, the study could help in a search of genetic factors involved in this complex metabolic disorder in human.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WOKWRatDyslipidemias  IAGP compared to DA/KRGD 
WOKWRathyperinsulinism  IAGP compared to DA/KRGD 
Bw83RatMetabolic Syndrome  TAS  RGD 
Bw84RatMetabolic Syndrome  TAS  RGD 
Gluco39RatMetabolic Syndrome  TAS  RGD 
Gluco40RatMetabolic Syndrome  TAS  RGD 
Insul11RatMetabolic Syndrome  TAS  RGD 
Scl60RatMetabolic Syndrome  TAS  RGD 
Scl61RatMetabolic Syndrome  TAS  RGD 
Slep5RatMetabolic Syndrome  TAS  RGD 
Slep6RatMetabolic Syndrome  TAS  RGD 
Stl22RatMetabolic Syndrome  TAS  RGD 
Bw83Ratobesity  IAGP  RGD 
Bw84Ratobesity  IAGP  RGD 
WOKWRatobesity  IAGP compared to DA/KRGD 

Phenotype Annotations    Click to see Annotation Detail View

Objects Annotated

QTLs
Bw83  (Body weight QTL 83)
Bw84  (Body weight QTL 84)
Gluco39  (Glucose level QTL 39)
Gluco40  (Glucose level QTL 40)
Insul11  (Insulin level QTL 11)
Scl60  (Serum cholesterol level QTL 60)
Scl61  (Serum cholesterol level QTL 61)
Slep5  (Serum leptin concentration QTL 5)
Slep6  (Serum leptin concentration QTL 6)
Stl22  (Serum triglyceride level QTL 22)

Strains
DA/K  (Dark Agouti/Karlsburg)
WOKW  (NA)
WOKW/K  (NA)

Objects referenced in this article
QTL Bw18 Body weight QTL 18 Rattus norvegicus
QTL Niddm1 Non-insulin dependent diabetes mellitus QTL 1 Rattus norvegicus
QTL Niddm7 Non-insulin dependent diabetes mellitus QTL 7 Rattus norvegicus
Strain WOKA null Rattus norvegicus

Additional Information