RGD Reference Report - Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat. - Rat Genome Database

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Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat.

Authors: Tsuji, A  Nishikawa, T  Mori, M  Suda, K  Nishimori, I  Nishimura, M 
Citation: Tsuji A, etal., Genomics 2001 Jun 15;74(3):365-9.
RGD ID: 619682
Pubmed: PMID:11414764   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.2001.6557   (Journal Full-text)

A causative gene mutation is still undefined in approximately half of patients with hereditary pancreatitis, and no genetic factor has been identified in most patients with sporadic chronic pancreatitis. To identify a pancreatitis-associated gene, we performed a quantitative trait locus (QTL) analysis for the traits of chronic pancreatitis and diabetes mellitus in WBN/Kob rats. We identified two highly significant QTLs for chronic pancreatitis and/or hyperinsulinemia on chromosomes 7 and X. These QTLs were located on completely different chromosomal regions from those of causative genes that have been reported for human chronic pancreatitis: PRSS1, CFTR, and SPINK1. For these QTLs, prevalences of the WBN/Kob allele significantly increased in the rats with chronic pancreatitis. These findings indicate that chronic pancreatitis in WBN/Kob rats is controlled by multiple genes, and a genetic analysis in WBN/Kob rats might be useful for gene targeting for human chronic pancreatitis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw13Rathyperinsulinism  IDA  RGD 
Insul4Rathyperinsulinism  IDA  RGD 
Bw12Ratobesity  IAGP  RGD 
Bw13Ratpancreatitis  IDA  RGD 
Insul4Ratpancreatitis  IDA  RGD 
Panci1Ratpancreatitis  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw12Ratincreased body weight  QTM  RGD 
Bw13Ratincreased body weight  QTM  RGD 
Panci1Ratincreased body weight  QTM  RGD 
Bw13Ratincreased circulating insulin level  QTM  RGD 
Insul4Ratincreased circulating insulin level  QTM  RGD 
Insul4Ratincreased heart weight  QTM  RGD 
Bw13Ratpancreas inflammation  QTM  RGD 
Insul4Ratpancreas inflammation  QTM  RGD 
Panci1Ratpancreas inflammation  QTM  RGD 

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Objects Annotated

QTLs
Bw12  (Body weight QTL 12)
Bw13  (Body weight QTL 13)
Insul4  (Insulin level QTL 4)
Panci1  (Pancreas inflammation QTL 1)

Strains
BN/CrlCrlj  (NA)
WBN/KobSlc  (wistar bonn/kobori)


Additional Information