RGD Reference Report - Detection of a quantitative trait locus for intramuscular fat accumulation using the OLETF rat. - Rat Genome Database

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Detection of a quantitative trait locus for intramuscular fat accumulation using the OLETF rat.

Authors: Tanomura, H  Miyake, T  Taniguchi, Y  Manabe, N  Kose, H  Matsumoto, K  Yamada, T  Sasaki, Y 
Citation: Tanomura H, etal., J Vet Med Sci 2002 Jan;64(1):45-50.
RGD ID: 619672
Pubmed: (View Article at PubMed) PMID:11853145

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of intramuscular fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of intramuscular fat content by performing a whole-genome search using 108 F2 intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for intramuscular fat accumulation on rat chromosome 1 with a maximum lod score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of intramuscular fat content.

Annotation

Disease Annotations    
obesity  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

QTLs
Bw61  (Body weight QTL61)

Strains
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information