RGD Reference Report - Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat. - Rat Genome Database

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Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat.

Authors: Kovacs, P  Kloting, I 
Citation: Kovacs P and Kloting I, Arch Biochem Biophys 1998 Jun 1;354(1):139-43.
RGD ID: 619667
Pubmed: PMID:9633608   (View Abstract at PubMed)
DOI: DOI:10.1006/abbi.1998.0686   (Journal Full-text)

The spontaneously hypertensive rat (SHR/Mol) and the spontaneously diabetic BB/OK rat were crossed, and the F1 hybrids were backcrossed onto the BB/OK rat in order to search for quantitative trait loci (QTL) affecting serum total cholesterol and triglycerides on chromosomes 1, 3, 4, 10, 13, 18, and X. On chromosome 4 a QTL for triglyceride levels (lod score 3.3) was found within the region flanked by the D4Mit9 and Il-6 markers. Suggestive linkage (lod score 1.9) was found for total cholesterol on chromosome 4 at the Spr locus. Also, on chromosome 1 suggestive linkage for both investigated traits was found at marker D1Mit14 (lod score 1.9 for triglycerides, 2.1 for total cholesterol). The results of the study could contribute to the explanation of the genetic basis of lipid abnormalities, which are a common feature of pathological disorders such as coronary heart disease, hypertension, or non-insulin-dependent diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scl4RatHypercholesterolemia  IDA  RGD 
Scl5RatHypercholesterolemia  IDA  RGD 
Scl5RatHypertriglyceridemia  IDA  RGD 
Stl2RatHypertriglyceridemia  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BB.SHR-(D4Mit6-Spr)/KRatincreased circulating cholesterol level  IAGP compared to strain BB/OKRGD 
Scl4Ratincreased circulating cholesterol level  QTM  RGD 
BB.SHR-(D4Mit6-Spr)/KRatincreased circulating triglyceride level  IAGP compared to strain BB/OK RGD 
Scl5Ratincreased circulating triglyceride level  QTM  RGD 
Stl2Ratincreased circulating triglyceride level  QTM  RGD 

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Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

Scl4  (Serum cholesterol level QTL 4)
Scl5  (Serum cholesterol level QTL 5)
Stl2  (Serum triglyceride level QTL 2)

BB.SHR-(D4Mit6-Spr)/K  (NA)
BB/OK  (BioBreeding rat)
SHR/Mol  (NA)

Additional Information