RGD Reference Report - Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats (Rattus norvegicus). - Rat Genome Database

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Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats (Rattus norvegicus).

Authors: Kloting, I  Kovacs, P  Van den Brandt, J 
Citation: Kloting I, etal., Biochem Biophys Res Commun 2001 Jun 29;284(5):1126-33.
RGD ID: 619656
Pubmed: PMID:11414700   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5091   (Journal Full-text)

To study polygenetically inherited human diseases like hypertension, inbred rat strains are usually the preferred models. Because many inbred generations under optimized environmental conditions may have led to the survival of "silent" disease genes, we used a cross between one wild rat and genetically hypertensive SHR rats to analyze quantitative trait loci (QTLs) of blood pressure and related traits. The (Wild x SHR)F1 hybrids were transferred into a pathogen-free environment by wet-hysterectomy and were backcrossed onto SHR to generate first backcross hybrids (BC1). Progeny from one F1 female (n = 72) were phenotypically and genetically characterized to map QTLs. Significant, subsignificant, and suggestive evidence was found for more sex-specific than common linkage of blood pressure and most blood-pressure-related traits. Male- and female-specific regions were determined on different chromosomes for blood pressures (Chrs. 2 and 7 vs 5 and 11), body weight (Chrs. 10 vs 18), and blood glucose (Chr. 17 vs 20). A linkage in both males and females was shown for serum triglycerides on chromosomes 6 and 17, respectively, and blood glucose on chromosome 15. For serum total cholesterol, a significant linkage was found on chromosome 14 only in males. Our findings not only indicate the complex character of quantitative traits per se but also show impressively their dependence on sex, age, and strains in cosegregation analysis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stl1Ratarteriosclerosis  IAGP compared to Wild/K strainRGD 
Scl11RatHypercholesterolemia  IAGP compared to Wild/K strainRGD 
Gluco31Rathyperglycemia  IAGP compared to Wild/K strainRGD 
Bp101Rathypertension  IAGP compared to Wild/K strainRGD 
Bp102Rathypertension  IAGP compared to Wild/K strainRGD 
Bp103Rathypertension  IAGP compared to Wild/K strainRGD 
Bp104Rathypertension  IAGP compared to Wild/K strainRGD 
SHR/MolRathypertension MODEL: spontaneousIAGP compared to Wild/K strainRGD 
Stl1RatHypertriglyceridemia  IAGP compared to Wild/K strainRGD 
Bw10Ratobesity  IAGP compared to Wild/K strainRGD 
Bw11Ratobesity  IAGP compared to Wild/K strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHR/MolRatdecreased circulating glucose level  IAGP compared to Wild/K strainRGD 
SHR/MolRatdecreased circulating triglyceride level sexual_dimorphismIAGP in males, compared to Wild/K strainRGD 
SHR/MolRathypertension  IAGP  RGD 
Bw10Ratincreased body weight  IAGP compared to Wild/K strainRGD 
Bw11Ratincreased body weight  IAGP compared to Wild/K strainRGD 
SHR/MolRatincreased circulating cholesterol level sexual_dimorphismIAGP in males, compared to Wild/K strainRGD 
Scl11Ratincreased circulating cholesterol level  IAGP compared to Wild/K strainRGD 
Gluco31Ratincreased circulating glucose level  IAGP compared to Wild/K strainRGD 
Stl1Ratincreased circulating triglyceride level  IAGP compared to Wild/K strainRGD 
Bp101Ratincreased systemic arterial blood pressure  IAGP compared to Wild/K strainRGD 
Bp102Ratincreased systemic arterial blood pressure  IAGP compared to Wild/K strainRGD 
Bp103Ratincreased systemic arterial blood pressure  IAGP compared to Wild/K strainRGD 
Bp104Ratincreased systemic arterial blood pressure  IAGP compared to Wild/K strainRGD 
SHR/MolRatincreased systemic arterial systolic blood pressure  IAGP compared to Wild/K strainRGD 

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Objects Annotated

QTLs
Bp101  (Blood pressure QTL 101)
Bp102  (Blood pressure QTL 102)
Bp103  (Blood pressure QTL 103)
Bp104  (Blood pressure QTL 104)
Bw10  (Body weight QTL 10)
Bw11  (Body weight QTL 11)
Gluco31  (Glucose level QTL 31)
Scl11  (Serum cholesterol level QTL 11)
Stl1  (Serum triglyceride level QTL 1)

Strains
SHR/Mol  (NA)
Wild/K  (NA)


Additional Information