RGD Reference Report - Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. - Rat Genome Database

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Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat.

Authors: Pravenec, M  Zidek, V  Musilova, A  Vorlicek, J  Kren, V  St Lezin, E  Kurtz, TW 
Citation: Pravenec M, etal., J Hypertens 2001 Jun;19(6):1061-4.
RGD ID: 619651
Pubmed: PMID:11403354   (View Abstract at PubMed)

OBJECTIVES: Total genome scans of genetically segregating populations derived from the spontaneously hypertensive rat (SHR) and other rat models of hypertension have suggested the presence of quantitative trait loci (QTL) regulating blood pressure and cardiac mass on multiple chromosomes, including chromosome 2. The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2. DESIGN: A new congenic strain was derived by replacing a segment of chromosome 2 in the SHR between D2Rat171 and D2Arb24 with the corresponding chromosome segment from the normotensive Brown Norway rat. Arterial pressures were directly monitored in conscious rats by radiotelemetry. RESULTS: We found that the SHR congenic strain (SHR-2) carrying a segment of chromosome 2 from the Brown Norway rat had significantly lower systolic and diastolic blood pressures than the SHR progenitor strain. The attenuation of hypertension in the SHR-2 congenic strain versus the SHR progenitor strain was accompanied by significant amelioration of cardiac hypertrophy. CONCLUSIONS: These findings demonstrate that gene(s) with major effects on blood pressure exist in the differential segment of chromosome 2 trapped within the new SHR.BN congenic strain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cardiomegaly  IDA 619651 RGD 
hypertension  IDA 619651 RGD 
hypertension MODEL: spontaneousIAGP 619651compared to SHR.BN-(D2Rat171-D2Arb24)/Ipcv strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cardiac hypertrophy  IAGP 619651 RGD 
decreased heart weight  IAGP 619651compared to SHR/OlaIpcv strainRGD 
decreased systemic arterial diastolic blood pressure  IAGP 619651compared to SHR/OlaIpcv strainRGD 
decreased systemic arterial systolic blood pressure  IAGP 619651compared to SHR/OlaIpcv strainRGD 
increased body weight  IAGP 619651compared to SHR/OlaIpcv strainRGD 
increased systemic arterial blood pressure  IAGP 619651 RGD 

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Objects Annotated

QTLs
Bp105  (Blood pressure QTL 105)


Additional Information