RGD Reference Report - Aging and salt-loading modulate blood pressure QTLs in rats. - Rat Genome Database

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Aging and salt-loading modulate blood pressure QTLs in rats.

Authors: Mashimo, T  Nabika, T  Matsumoto, C  Tamada, T  Ueno, K  Sawamura, M  Ikeda, K  Kato, N  Nara, Y  Yamori, Y 
Citation: Mashimo T, etal., Am J Hypertens 1999 Nov;12(11 Pt 1):1098-104.
RGD ID: 619634
Pubmed: PMID:10604486   (View Abstract at PubMed)

To evaluate the effects of nongenetic factors, aging, and salt-loading on the quantitative trait loci (QTLs) for blood pressure (BP), we conducted a genome-wide linkage analysis using multiple sets of BP measurements in 125 male F2 generation cross derived from stroke-prone spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. The experiment was arranged in two stages. In the first stage, corresponding to the developing period of the rats, BP was measured repeatedly without loading of salt; this continued until the rats were 5 months of age. In the second stage, after the baseline BP leveled off, 1% salt water was given to the rats and BP was monitored for the subsequent 7 months. Genome scanning was performed using 201 markers. In the developing period, three QTLs were identified on chromosomes 1, 3, and 4 (logarithmic odds [LOD] scores of 5.6, 3.1, and 3.2, respectively), which had peaks at 8 or 10 weeks of age. In the latter salt-loading stage, QTLs for BP were detected on chromosomes 1 and 10 (LOD scores 4.6 and 4.5, respectively). When the BP increase during salt-loading was analyzed as a phenotype, however, only the region on chromosome 10 showed linkage at a suggestive level (LOD score 3.2). The present study provides experimental evidence that QTLs for BP could be modulated by nongenetic factors, such as aging and salt-loading.



Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp84  (Blood pressure QTL 84)
Bp85  (Blood pressure QTL 85)
Bp86  (Blood pressure QTL 86)
Bp87  (Blood pressure QTL 87)

Strains
SHRSP/Izm  (NA)
WKY/Izm  (Wistar-Kyoto)


Additional Information