RGD Reference Report - Is the nitric oxide system involved in genetic hypertension in Dahl rats? - Rat Genome Database

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Is the nitric oxide system involved in genetic hypertension in Dahl rats?

Authors: Deng, AY 
Citation: Deng AY Kidney Int 1998 Jun;53(6):1501-11.
RGD ID: 619625
Pubmed: PMID:9607182   (View Abstract at PubMed)
DOI: DOI:10.1046/j.1523-1755.1998.00933.x   (Journal Full-text)

To address this issue, a series of genetic tests were carried out. Linkage studies showed that the inducible nitric oxide synthase (Nos2) locus cosegregated with blood pressure in three F2 populations originated from crosses of Dahl salt-sensitive (S) rats with rats of various normotensive strains. However, the brain nitric oxidase synthase (Nos1) and endothelial nitric oxide synthase (Nos3) loci did not cosegregate with blood pressure in five F2 populations. Thus, only Nos2, but not Nos1 and Nos3, was considered as a candidate gene for being a quantitative trait locus (QTL) for blood pressure in the S rat. To further test this hypothesis, congenic strains were constructed by substituting regions on Chromosome 10 of the S rat with the homologous regions of the Milan normotensive (MNS) rat. Results showed that the chromosome region including Nos2 did not contain a blood pressure QTL. In consequence, Nos2 per se is not supported as a candidate QTL capable of causing a blood pressure difference between the S and MNS rats. Nevertheless, the nitric oxide system appears to be involved secondarily in the regulation of blood pressure in the S rat, as evidenced by physiological data.



Disease Annotations    
hypertension  (IAGP,IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp250  (Blood pressure QTL 250)
Bp76  (Blood pressure QTL 76)

Objects referenced in this article
Marker D10M11Mit84 D10M11Mit84 Rattus norvegicus
Strain SS.MNS-(Aldoc-D10Mco1)/Jr null Rattus norvegicus
Strain SS.MNS-(D10Mco14-D10Mit11)/Jr null Rattus norvegicus
Strain SS.MNS-(Vamp2-D10M11Mit84)/Mco null Rattus norvegicus

Additional Information