RGD Reference Report - Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. - Rat Genome Database

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Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.

Authors: Rettig, J  Heinemann, SH  Wunder, F  Lorra, C  Parcej, DN  Dolly, JO  Pongs, O 
Citation: Rettig J, etal., Nature 1994 May 26;369(6478):289-94.
RGD ID: 61642
Pubmed: PMID:8183366   (View Abstract at PubMed)
DOI: DOI:10.1038/369289a0   (Journal Full-text)

Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain is enhanced by the association of two different types of subunits, the membrane-bound, poreforming alpha-subunits and a peripheral beta-subunit. We have cloned a beta-subunit (Kv beta 1) that is specifically expressed in the rat nervous system. Association of Kv beta 1 with alpha-subunits confers rapid A-type inactivation on non-inactivating Kv1 channels (delayed rectifiers) in expression systems in vitro. This effect is mediated by an inactivating ball domain in the Kv beta 1 amino terminus.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnab1Ratnegative regulation of delayed rectifier potassium channel activity  IDA  RGD 
Kcnab1Ratregulation of delayed rectifier potassium channel activity involved_inIDA PMID:8183366UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnab1Ratpotassium channel regulator activity enablesIDA PMID:8183366UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnab1  (potassium voltage-gated channel subfamily A regulatory beta subunit 1)

Objects referenced in this article
Gene Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 Rattus norvegicus
Gene Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 Rattus norvegicus

Additional Information