RGD Reference Report - The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats.

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The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats.
Authors:	Ciccocioppo, Roberto Economidou, Daina Fedeli, Amalia Massi, Maurizio
Citation:	Ciccocioppo R, etal., Physiol Behav. 2003 Jun;79(1):121-8. doi: 10.1016/s0031-9384(03)00112-4.
RGD ID:	616363155
Pubmed:	PMID:12818717 (View Abstract at PubMed)
DOI:	DOI:10.1016/s0031-9384(03)00112-4 (Journal Full-text)
The intracerebroventricular administration of the 17 amino acid peptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor (previously referred to as ORL-1 or OP4 receptor), reduces voluntary 10% ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Studies aimed at the pharmacological characterization of the receptor, which mediates the effect, have shown that the C-terminal 13 amino acid sequence is crucial for activity and that the selective NOP receptor antagonist [Nphe(1)]N/OFQ(1-13)NH(2) blocks the effect of N/OFQ on ethanol drinking. In place conditioning studies, N/OFQ abolishes the conditioned place preference (CPP) induced by ethanol in msP rats, or by morphine in nonselected Wistar rats; these findings suggest that N/OFQ is able to abolish the rewarding properties of ethanol and morphine. Moreover, N/OFQ inhibits reinstatement of alcohol-seeking behavior induced to electric footshock stress, as well as reinstatement of alcohol-seeking behavior induced by ethanol-paired cues. Together, these findings suggest that N/OFQ and its receptor may represent an interesting target for pharmacological treatment of alcohol abuse.

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RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
PNOC	Human	Alcohol-Related Disorders	treatment	ISO	Pnoc (Rattus norvegicus)		RGD
Pnoc	Rat	Alcohol-Related Disorders	treatment	IMP			RGD
Pnoc	Mouse	Alcohol-Related Disorders	treatment	ISO	Pnoc (Rattus norvegicus)		RGD
sP	Rat	Alcohol-Related Disorders	treatment	IMP			RGD

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Biological Process

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Pnoc	Rat	drinking behavior		IMP			RGD

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Mammalian Phenotype

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Pnoc	Rat	abnormal drug-induced reinstatement of an extinguished operant behavior for a drug reinforcer	treatment	IMP			RGD
sP	Rat	abnormal drug-induced reinstatement of an extinguished operant behavior for a drug reinforcer	treatment	IMP			RGD
Pnoc	Rat	alcohol preference	treatment	IMP			RGD
sP	Rat	alcohol preference	treatment	IMP			RGD

Objects Annotated

Genes (Rattus norvegicus)

Pnoc (prepronociceptin)

Genes (Mus musculus)

Pnoc (prepronociceptin)

Genes (Homo sapiens)

PNOC (prepronociceptin)

Strains

sP (Sardinian alcohol-preferring rats)

Additional Information

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats.

Mammalian Phenotype