RGD Reference Report - Blood pressure QTL that differentiate dahl salt-sensitive and spontaneously hypertensive rats - Rat Genome Database

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Blood pressure QTL that differentiate dahl salt-sensitive and spontaneously hypertensive rats

Authors: Garrett, MR  Saad, Y  Dene, H  Rapp, JP 
Citation: Garrett MR, etal., Physiol Genomics 2000 Jun 29;3(1):33-8.
RGD ID: 61516
Web Url: http://physiolgenomics.physiology.org/cgi/content/abstract/3/1/33
Pubmed: PMID:11015598   (View Abstract at PubMed)

Our purpose was to define quantitative trait loci (QTL) for blood pressure that differ between two widely used hypertensive rat strains, the Dahl salt-sensitive (S) rat and the spontaneously hypertensive rat (SHR). A genome scan was done on an F(2) (S x SHR) population fed 8% NaCl for 4 wk. Three blood pressure QTL were detected, one on each of rat chromosomes (chr) 3, 8, and 9. For the chr 3 QTL the SHR allele increased blood pressure, and for chr 8 and 9 the S allele increased blood pressure. The QTL on chr 9 was exceptionally strong, having a LOD score of 7.3 and accounting for 30% of the phenotypic variance and a difference of 40 mmHg between homozygotes. A review of the literature in conjunction with the present data suggests that S and SHR are not different for the previously described prominent blood pressure QTL on chr 1, 2, 10, and 13. QTL for body weight on chr 4, 12, 18, and 20, each with an effect of about 30 g, were incidentally observed.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp62Rathypertension  IDA  RGD 
Bp92Rathypertension  IDA  RGD 
Bw108Rathypertension  IAGP  RGD 
Bw109Rathypertension  IAGP  RGD 
Bw110Rathypertension  IAGP  RGD 
Bw111Rathypertension  IAGP  RGD 
Cm28Rathypertension  IAGP  RGD 
SS/JrRathypertension MODEL: inducedIAGPcontrolled sodium content dietcompared to SS/Jr strainRGD 

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Mammalian Phenotype


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Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

QTLs
Bp62  (Blood pressure QTL 62)
Bp92  (Blood pressure QTL 92)
Bw108  (Body weight QTL 108)
Bw109  (Body weight QTL 109)
Bw110  (Body weight QTL 110)
Bw111  (Body weight QTL 111)
Cm28  (Cardiac mass QTL 28)

Strains
SHR/NHsd  (NA)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
QTL Mcs7 Mammary carcinoma susceptibility QTL 7 Rattus norvegicus

Additional Information