RGD Reference Report - Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease - Rat Genome Database

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Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease

Authors: Rubattu, S  Volpe, M  Kreutz, R  Ganten, U  Ganten, D  Lindpaintner, K 
Citation: Rubattu S, etal., Nat Genet 1996 Aug;13(4):429-34
RGD ID: 61093
Pubmed: PMID:8696337   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0896-429   (Journal Full-text)

Stroke is a complex disorder with a poorly understood multifactorial and polygenic aetiology. We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a genome-wide screen in the resultant F2 cohort where latency until stroke, but not hypertension (a major confounder) segregated. We identified three major quantitative trait loci, STR1-3, with lod scores of 7.4, 4.7 and 3.0, respectively, that account for 28% of the overall phenotypic variance. STR2 colocalizes with the genes encoding atrial and brain natriuretic factor, peptides with important vasoactive properties. Our results demonstrate the existence of primary, blood pressure-independent genetic factors predisposing to a complex form of stroke.



Disease Annotations    
Stroke  (IAGP,IDA)

Phenotype Annotations    

Mammalian Phenotype
brain ischemia  (IAGP,QTM)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Objects Annotated

QTLs
Strs1  (Sensitivity to stroke QTL 1)
Strs2  (Sensitivity to stroke QTL 2)
Strs3  (Sensitivity to stroke QTL 3)

Strains
SHR/Bbb  (NA)
SHRSP  (Spontaneously Hypertensive Rat, Stroke Prone)
SHRSP/Bbb  (NA)

Objects referenced in this article
Marker D4Mgh16 D4Mgh16 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Gene Nppa natriuretic peptide A Rattus norvegicus
Strain SHRSR/Bbb Spontaneously Hypertensive Rat, Stroke Resistant Rattus norvegicus

Additional Information