RGD Reference Report - Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease - Rat Genome Database

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Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease

Authors: Rubattu, S  Volpe, M  Kreutz, R  Ganten, U  Ganten, D  Lindpaintner, K 
Citation: Rubattu S, etal., Nat Genet 1996 Aug;13(4):429-34
RGD ID: 61093
Pubmed: (View Article at PubMed) PMID:8696337
DOI: Full-text: DOI:10.1038/ng0896-429

Stroke is a complex disorder with a poorly understood multifactorial and polygenic aetiology. We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a genome-wide screen in the resultant F2 cohort where latency until stroke, but not hypertension (a major confounder) segregated. We identified three major quantitative trait loci, STR1-3, with lod scores of 7.4, 4.7 and 3.0, respectively, that account for 28% of the overall phenotypic variance. STR2 colocalizes with the genes encoding atrial and brain natriuretic factor, peptides with important vasoactive properties. Our results demonstrate the existence of primary, blood pressure-independent genetic factors predisposing to a complex form of stroke.



Disease Annotations    
Stroke  (IAGP,IDA)

Phenotype Annotations    

Mammalian Phenotype
brain ischemia  (IAGP,QTM)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Objects Annotated

QTLs
Strs1  (Sensitivity to stroke QTL 1)
Strs2  (Sensitivity to stroke QTL 2)
Strs3  (Sensitivity to stroke QTL 3)

Strains
SHRSP  (Spontaneously Hypertensive Rat, Stroke Prone)

Objects referenced in this article
Marker D4Mgh16 D4Mgh16 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Gene Nppa natriuretic peptide A Rattus norvegicus
Strain SHR/Bbb null Rattus norvegicus
Strain SHRSR/Bbb Spontaneously Hypertensive Rat, Stroke Resistant Rattus norvegicus

Additional Information