RGD Reference Report - Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease

Authors: Rubattu, S  Volpe, M  Kreutz, R  Ganten, U  Ganten, D  Lindpaintner, K 
Citation: Rubattu S, etal., Nat Genet 1996 Aug;13(4):429-34
RGD ID: 61093
Pubmed: PMID:8696337   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0896-429   (Journal Full-text)

Stroke is a complex disorder with a poorly understood multifactorial and polygenic aetiology. We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a genome-wide screen in the resultant F2 cohort where latency until stroke, but not hypertension (a major confounder) segregated. We identified three major quantitative trait loci, STR1-3, with lod scores of 7.4, 4.7 and 3.0, respectively, that account for 28% of the overall phenotypic variance. STR2 colocalizes with the genes encoding atrial and brain natriuretic factor, peptides with important vasoactive properties. Our results demonstrate the existence of primary, blood pressure-independent genetic factors predisposing to a complex form of stroke.



Disease Annotations    
Stroke  (IAGP,IDA)

Phenotype Annotations    

Mammalian Phenotype
brain ischemia  (IAGP,QTM)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement


Objects Annotated

QTLs
Strs1  (Sensitivity to stroke QTL 1)
Strs2  (Sensitivity to stroke QTL 2)
Strs3  (Sensitivity to stroke QTL 3)

Strains
SHR/Bbb  (NA)
SHRSP  (Spontaneously Hypertensive Rat, Stroke Prone)
SHRSP/Bbb  (NA)

Objects referenced in this article
Marker D4Mgh16 D4Mgh16 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Gene Nppa natriuretic peptide A Rattus norvegicus
Strain SHRSR/Bbb Spontaneously Hypertensive Rat, Stroke Resistant Rattus norvegicus

Additional Information