RGD Reference Report - A genetic linkage map of the laboratory rat, Rattus norvegicus. - Rat Genome Database

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A genetic linkage map of the laboratory rat, Rattus norvegicus.

Authors: Jacob, HJ  Brown, DM  Bunker, RK  Daly, MJ  Dzau, VJ  Goodman, A  Koike, G  Kren, V  Kurtz, T  Lernmark, A  Et, AL 
Citation: Jacob HJ, etal., Nat Genet 1995 Jan;9(1):63-9
RGD ID: 61090
Pubmed: PMID:7704027   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0195-63   (Journal Full-text)

We report the construction of the first complete genetic linkage map of the laboratory rat. By testing 1171 simple sequence length polymorphisms (SSLPs), we have identified 432 markers that show polymorphisms between the SHR and BN rat strains and mapped them in a single (SHR x BN) F2 intercross. The loci define 21 large linkage groups corresponding to the 21 rat chromosomes, together with a pair of nearby markers on chromosome 9 that are not linked to the rest of the map. Because 99.5% of the markers fall into one of the 21 large linkage groups, the maps appear to cover the vast majority of the rat genome. The availability of the map should facilitate whole genome scans for genes underlying qualitative and quantitative traits relevant to mammalian physiology and pathobiology.



Objects referenced in this article
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D1Mit6 D1Mit6 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Marker D1Mit2 D1Mit2 Rattus norvegicus
Strain ACI/N A X C 9935, Irish Rattus norvegicus
Strain FHH Fawn Hooded Hypertensive Rattus norvegicus
QTL Rf1 Renal disease susceptibility QTL 1 Rattus norvegicus
QTL Rf2 Renal disease susceptibility QTL 2 Rattus norvegicus

Additional Information