RGD Reference Report - Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. - Rat Genome Database

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Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.

Authors: Vingsbo, C  Sahlstrand, P  Brun, JG  Jonsson, R  Saxne, T  Holmdahl, R 
Citation: Vingsbo C, etal., Am J Pathol 1996 Nov;149(5):1675-83
RGD ID: 61088
Pubmed: PMID:8909256   (View Abstract at PubMed)
PMCID: PMC1865278   (View Article at PubMed Central)

We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte infiltration. The initial development as well as the chronic stage of pristane-induced arthritis was ameliorated by treatment with antibodies to the alpha beta-T-cell receptor showing that the disease is T cell dependent. Increased levels of interleukin in serum was seen after pristane injection but not during the chronic stage of arthritis. Joint erosions were accompanied by elevated serum levels of cartilage oligomeric matrix protein. Comparison of MHC congenic LEW strains showed that the severity and chronicity of arthritis varied among the different MHC haplotypes. Rats with RT1f haplotype showed a significantly higher susceptibility to pristane-induced arthritis. A strong influence of non-MHC genes was also suggested by the variability of arthritis susceptibility among different strains with the same MHC haplotype; the most susceptible background was the DA and the least susceptible was the E3. Arthritis induced with a well defined nonimmunogenic adjuvant, with a disease course that closely resembles that of rheumatoid arthritis, makes a suitable animal model for future studies of the pathology and genetics of rheumatoid arthritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DARatExperimental Arthritis inducedIAGPpristane RGD 
DXE1/ZtmRatExperimental Arthritis penetranceIAGPpristane RGD 
DXE2/ZtmRatExperimental Arthritis penetranceIAGPpristane RGD 
LEWRatExperimental Arthritis inducedIAGPpristane RGD 
LEW.1FRatExperimental Arthritis inducedIAGPpristane RGD 
LEW.1NRatExperimental Arthritis penetranceIAGPpristane RGD 
DARatrheumatoid arthritis MODEL: inducedIAGPpristaneE3RGD 
E3Ratrheumatoid arthritis MODEL: controlIAGPpristaneDARGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


Objects Annotated

Strains
DA  (DA)
DXE1/Ztm  (NA)
DXE2/Ztm  (NA)
E3  (NA)
LEW  (Lewis)
LEW.1F  (NA)
LEW.1N  (NA)

Objects referenced in this article
Strain DXE3/Ztm null Rattus norvegicus
QTL Pia1 Pristane induced arthritis QTL 1 Rattus norvegicus

Additional Information