RGD Reference Report - Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat.

Authors: Bottger, A  Van Lith, HA  Kren, V  Krenova, D  Bila, V  Vorlicek, J  Zidek, V  Musilova, A  Zdobinska, M  Wang, JM  Van Zutphen, BF  Kurtz, TW  Pravenec, M 
Citation: Bottger A, etal., J Clin Invest 1996 Aug 1;98(3):856-62
RGD ID: 61079
Pubmed: (View Article at PubMed) PMID:8698878
DOI: Full-text: DOI:10.1172/JCI118858

The frequent coincidence of hypertension and dyslipidemia suggests that related genetic factors might underlie these common risk factors for cardiovascular disease. To investigate whether quantitative trait loci (QTLs) regulating lipid levels map to chromosomes known to contain genes regulating blood pressure, we used a genome scanning approach to map QTLs influencing cholesterol and phospholipid phenotypes in a large set of recombinant inbred strains and in congenic strains derived from the spontaneously hypertensive rat and normotensive Brown-Norway (BN.Lx) rat fed normal and high cholesterol diets. QTLs regulating lipid phenotypes were mapped by scanning the genome with 534 genetic markers. A significant relationship (P < 0.00006) was found between basal HDL2 cholesterol levels and the D19Mit2 marker on chromosome 19. Analysis of congenic strains of spontaneously hypertensive rat indicated that QTLs regulating postdietary lipid phenotypes exist also on chromosomes 8 and 20. Previous studies in the recombinant inbred and congenic strains have demonstrated the presence of blood pressure regulatory genes in corresponding segments of chromosomes 8, 19, and 20. These findings provide support for the hypothesis that blood pressure and certain lipid subfractions can be modulated by linked genes or perhaps even the same genes.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement

Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
BN-Lx/Cub SHR/OlaIpcv SHR.BN-(D8Mit5-D8Mgh6)/Ipcv
SHR.BN-RT1n

Objects Annotated

QTLs
Scl12  (Serum cholesterol level QTL 12)
Scl13  (Serum cholesterol level QTL 13)
Scl23  (Serum cholesterol level QTL 23)

Strains
BN-Lx  (NA)
SHR/Ola  (NA)

Objects referenced in this article
Marker D19Mit2 D19Mit2 Rattus norvegicus
Gene Il6 interleukin 6 Rattus norvegicus
Strain SHR.BN-RT1n null Rattus norvegicus

Additional Information