RGD Reference Report - Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. - Rat Genome Database

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Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

Authors: Kloting, I  Chmidt S, S  Kovacs, P 
Citation: Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
RGD ID: 61077
Pubmed: PMID:9571179   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.8464   (Journal Full-text)

By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for diabetes development in the BB rat. Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Because mapping results need not be consistent among different crosses, we genetically analysed a new cross population using diabetic BB/OK and diabetes-resistant SHR/Mol rats analysing 73 microsatellite markers. The genetic analysis of Iddm1 and Iddm2 homozygous [(BB/OK x SHR)F1 x BB/OK] first backcross hybrids (BC1) confirmed the action of Iddm3 and one predisposing non-MHC locus, Iddm4, near Ighe/D6Mgh2 on chromosome 6 and one protective locus, Iddm5r(esistance), detected around Igf2/Tnt on chromosome 1. From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes.

Disease Annotations    

Objects Annotated

Iddm16  (Insulin dependent diabetes mellitus QTL 16)
Iddm4  (Insulin dependent diabetes mellitus QTL 4)
Iddm8  (Insulin dependent diabetes mellitus QTL 8)

BB/OK  (BioBreeding rat)
DA  (DA)
SHR/Mol  (NA)

Objects referenced in this article
Marker D6Mgh2 D6Mgh2 Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat101)/K null Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat3)/K null Rattus norvegicus
Strain BB/N BioBreeding rat Rattus norvegicus
QTL Iddm9 Insulin dependent diabetes mellitus QTL 9 Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information