RGD Reference Report - Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

Authors: Kloting, I  Chmidt S, S  Kovacs, P 
Citation: Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
RGD ID: 61077
Pubmed: PMID:9571179   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.8464   (Journal Full-text)

By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for diabetes development in the BB rat. Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Because mapping results need not be consistent among different crosses, we genetically analysed a new cross population using diabetic BB/OK and diabetes-resistant SHR/Mol rats analysing 73 microsatellite markers. The genetic analysis of Iddm1 and Iddm2 homozygous [(BB/OK x SHR)F1 x BB/OK] first backcross hybrids (BC1) confirmed the action of Iddm3 and one predisposing non-MHC locus, Iddm4, near Ighe/D6Mgh2 on chromosome 6 and one protective locus, Iddm5r(esistance), detected around Igf2/Tnt on chromosome 1. From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes.



Disease Annotations    

Objects Annotated

QTLs
Iddm16  (Insulin dependent diabetes mellitus QTL 16)
Iddm4  (Insulin dependent diabetes mellitus QTL 4)
Iddm8  (Insulin dependent diabetes mellitus QTL 8)

Strains
BB/OK  (BioBreeding rat)
DA  (DA)
SHR/Mol  (NA)

Objects referenced in this article
Marker D6Mgh2 D6Mgh2 Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat101)/K null Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat3)/K null Rattus norvegicus
Strain BB/N BioBreeding rat Rattus norvegicus
QTL Iddm9 Insulin dependent diabetes mellitus QTL 9 Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information