RGD Reference Report - Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat. - Rat Genome Database

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Chromosomal mapping of a major quantitative trait locus regulating compensatory renal growth in the rat.

Authors: Pravenec, M  Zidek, V  Musilova, A  Kren, V  Bila, V  Di Nicolantonio, R 
Citation: Pravenec M, etal., J Am Soc Nephrol 2000 Jul;11(7):1261-5
RGD ID: 61071
Web Url: http://www.jasn.org/cgi/content/abstract/11/7/1261
Pubmed: PMID:10864582   (View Abstract at PubMed)

Despite extensive research conducted over the past century, the mechanisms of compensatory renal growth (CRG) remain a mystery. Insight into the mechanisms that regulate CRG might be gained by identifying genetic factors that influence this complex phenotype. In a large set of recombinant inbred strains derived from the spontaneously hypertensive rat and the Brown Norway rat, a genome scan for quantitative trait loci (QTL) that regulate CRG was performed. The CRG score was expressed as a ratio of the weight of the remnant right kidney at 8 wk of age to the weight of the left kidney at 5 wk of age, both adjusted for body weight. QTL mapping was performed using Map Manager QT and the strain distribution patterns of more than 600 genetic markers. It was found that CRG after unilateral nephrectomy is a multifactorially determined trait with a substantial genetic component. The heritability of CRG approached 40%. Genome wide scan analysis revealed significant evidence of linkage to a region of rat chromosome 4 designated Crg 1 that accounted for more than 50% of the additive genetic variance of CRG in the recombinant inbred strains. The detection of a major QTL influencing CRG in the rat should provide new opportunities for identifying mechanisms that regulate this historically enigmatic phenomenon and may also have implications for research on the pathogenesis of end-stage kidney disease.



Disease Annotations    
kidney disease  (IAGP)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Coreg2  (Compensatory renal growth QTL 2)

Strains
BN-Lx/Cub  (Brown Norway with polydactyly-luxate)
SHR/Ola  (NA)

Objects referenced in this article
Gene Cacna1c calcium voltage-gated channel subunit alpha1 C Rattus norvegicus
Strain PD/Cub polydactylous Rattus norvegicus

Additional Information