A genetic linkage map of rat chromosome 20 derived from five F2 crosses.
Authors:
Kawahito, Y Remmers, EF Wilder, RL Longman, RE Gulko, PS Wang, J Chen, S Chang, L Reese, VR Dracheva, S Ge, L Hoffman, JH Shepard, J Cannon, GW Griffiths, MM
Citation:
Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
Rats are used extensively in many fields of biomedical research, and more than 140 inbred strains are avaiable. This wide array of rat inbred strains facilitates studies on the genetic basis of disease models such as hypertension, diabetes, autoimmunity, alcoholism, ans so on. Progress in identifying quantitative trait loci (QTLs) regulating suseptibility/resistance in the model diseases is largely, due to the development of the genetic maps composed of polymorphic chromosomal markers.