RGD Reference Report - Mapping autoimmunity genes. - Rat Genome Database
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Mapping autoimmunity genes.

Authors: Griffiths, M M  Encinas, J A  Remmers, E F  Kuchroo, V K  Wilder, R L 
Citation: Griffiths MM, etal., Curr Opin Immunol. 1999 Dec;11(6):689-700.
RGD ID: 61065
Pubmed: (View Article at PubMed) PMID:10631556

Rat and mouse models for the major human autoimmune/inflammatory diseases are under intense genetic scrutiny. Genome-wide linkage studies reveal that each model is regulated by multiple genetic loci. Many of these loci colocalize to homologous genomic regions associated with several different autoimmune diseases of mice, rats and humans. Candidate genes are being identified. Polymorphic alleles associated with these chromosomal segments may represent predisposing genetic elements common to a number of human diseases with very different clinical presentations.

Annotation

Objects referenced in this article
0 D2Mgh12 D2Mgh12 All species
0 ACI/N A X C 9935, Irish All species
0 Cd2 Cd2 molecule All species
0 Cd53 Cd53 molecule All species
0 Cia10 Collagen induced arthritis QTL 10 All species
0 Cia9 Collagen induced arthritis QTL 9 All species
0 DA/Bkl null All species
0 Il12b interleukin 12B All species
0 Il6r interleukin 6 receptor All species
0 Ngf nerve growth factor All species
0 Nras NRAS proto-oncogene, GTPase All species
0 Vcam1 vascular cell adhesion molecule 1 All species

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