RGD Reference Report - Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

Authors: Brown, DM  Provoost, AP  Daly, MJ  Lander, ES  Jacob, HJ 
Citation: Brown DM, etal., Nat Genet 1996 Jan;12(1):44-51
RGD ID: 61060
Pubmed: PMID:8528250   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0196-44   (Journal Full-text)

Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the fawn-hooded rat, an animal model of hypertension that develops chronic renal failure. Here, we report the localization of two genes, Rf-1 and Rf-2, responsible for about half of the genetic variation in key indices of renal impairment. In addition, we localize a gene, Bpfh-1, responsible for about 26% of the genetic variation in blood pressure. Rf-1 strongly affects the risk of renal impairment, but has no significant effect on blood pressure. Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rf1Ratend stage renal disease  IDA  RGD 
Rf2Ratend stage renal disease  IDA  RGD 
Bp197Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rf1Ratglomerulosclerosis  QTM  RGD 
Rf2Ratglomerulosclerosis  QTM  RGD 
Bp197Ratincreased systemic arterial blood pressure  QTM  RGD 
Rf1Ratincreased urine protein level  IDA  RGD 
Rf2Ratincreased urine protein level  IDA  RGD 
Objects Annotated

QTLs
Bp197  (Blood pressure QTL 197)
Rf1  (Renal disease susceptibility QTL 1)
Rf2  (Renal disease susceptibility QTL 2)

Strains
ACI/N  (A X C 9935, Irish)
FHH  (Fawn Hooded Hypertensive)
FHH/Eur  (NA)

Objects referenced in this article
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D1Mit6 D1Mit6 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Marker D1Mit2 D1Mit2 Rattus norvegicus
QTL Bp26 Blood pressure QTL 26 Rattus norvegicus
QTL Bp28 Blood pressure QTL 28 Rattus norvegicus
QTL Bp29 Blood pressure QTL 29 Rattus norvegicus
QTL Bp30 Blood pressure QTL 30 Rattus norvegicus
Gene Mt1-ps1 metallothionein 1, pseudogene 1 Rattus norvegicus

Additional Information