RGD Reference Report - Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. - Rat Genome Database

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Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat.

Authors: Brown, DM  Provoost, AP  Daly, MJ  Lander, ES  Jacob, HJ 
Citation: Brown DM, etal., Nat Genet 1996 Jan;12(1):44-51
RGD ID: 61060
Pubmed: PMID:8528250   (View Abstract at PubMed)
DOI: DOI:10.1038/ng0196-44   (Journal Full-text)

Hypertension, diabetes and hyperlipidemia are risk factors for life-threatening complications such as end-stage renal disease, coronary artery disease and stroke. Why some patients develop complications is unclear, but only susceptibility genes may be involved. To test this notion, we studied crosses involving the fawn-hooded rat, an animal model of hypertension that develops chronic renal failure. Here, we report the localization of two genes, Rf-1 and Rf-2, responsible for about half of the genetic variation in key indices of renal impairment. In addition, we localize a gene, Bpfh-1, responsible for about 26% of the genetic variation in blood pressure. Rf-1 strongly affects the risk of renal impairment, but has no significant effect on blood pressure. Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp197  (Blood pressure QTL 197)
Rf1  (Renal disease susceptibility QTL 1)
Rf2  (Renal disease susceptibility QTL 2)

Strains
ACI/N  (A X C 9935, Irish)
FHH  (Fawn Hooded Hypertensive)
FHH/Eur  (NA)

Objects referenced in this article
Marker D1Mgh12 D1Mgh12 Rattus norvegicus
Marker D1Mit6 D1Mit6 Rattus norvegicus
Marker D1Mit3 D1Mit3 Rattus norvegicus
Marker D1Mit2 D1Mit2 Rattus norvegicus
QTL Bp26 Blood pressure QTL 26 Rattus norvegicus
QTL Bp28 Blood pressure QTL 28 Rattus norvegicus
QTL Bp29 Blood pressure QTL 29 Rattus norvegicus
QTL Bp30 Blood pressure QTL 30 Rattus norvegicus
Gene Mt1-ps1 metallothionein 1, pseudogene 1 Rattus norvegicus

Additional Information