RGD Reference Report - Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. - Rat Genome Database

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Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.

Authors: Kren, V  Pravenec, M  Lu, S  Krenova, D  Wang, JM  Wang, N  Merriouns, T  Wong, A  St. Lezin, E  Lau, D  Szpirer, C  Szpirer, J  Kurtz, TW 
Citation: Kren V, etal., J Clin Invest 1997 Feb 15;99(4):577-81
RGD ID: 61054
Pubmed: PMID:9045857   (View Abstract at PubMed)
PMCID: PMC507837   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI119198   (Journal Full-text)

The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. Despite > 30 yr of research, the primary genetic lesions responsible for hypertension in the SHR remain undefined. In this report, we describe the construction and hemodynamic characterization of a congenic strain of SHR (SHR-Lx) that carries a defined segment of chromosome 8 from a normotensive strain of Brown-Norway rats (BN-Lx strain). Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats.



Disease Annotations    
hypertension  (IAGP)

Phenotype Annotations    
Objects Annotated

QTLs
Bp35  (Blood pressure QTL 35)
Cm81  (Cardiac mass QTL 81)

Objects referenced in this article
Marker D8Mit6 D8Mit6 Rattus norvegicus
Strain BN-Lx null Rattus norvegicus
QTL Bp22 Blood pressure QTL 22 Rattus norvegicus
QTL Bp39 Blood pressure QTL 39 Rattus norvegicus
Gene Rbp2 retinol binding protein 2 Rattus norvegicus
Strain SHR.BN-RT1n null Rattus norvegicus
Strain SHR/Ola null Rattus norvegicus

Additional Information