RGD Reference Report - Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. - Rat Genome Database

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Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.

Authors: Rapp, JP  Garrett, MR  Dene, H  Meng, H  Hoebee, B  Lathrop, GM 
Citation: Rapp JP, etal., Genomics 1998 Jul 15;51(2):191-6
RGD ID: 61053
Pubmed: (View Article at PubMed) PMID:9722941
DOI: Full-text: DOI:10.1006/geno.1998.5394

A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

QTLs
Bp34  (Blood pressure QTL 34)

Strains
SS.SR-Inha/Jr  (NA)

Objects referenced in this article
Marker D9Uia6 D9Uia6 Rattus norvegicus
Marker D9Uia9 D9Uia9 Rattus norvegicus
Gene Inha inhibin subunit alpha Rattus norvegicus
Strain SR/Jr Salt Resistant Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus

Additional Information