RGD Reference Report - Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1. - Rat Genome Database

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Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.

Authors: Gu, L  Dene, H  Deng, AY  Hoebee, B  Bihoreau, MT  James, M  Rapp, JP 
Citation: Gu L, etal., J Clin Invest 1996 Feb 1;97(3):777-88
RGD ID: 61049
Pubmed: PMID:8609235   (View Abstract at PubMed)
PMCID: PMC507116   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI118477   (Journal Full-text)

A genetic map for rat chromosome 1 was constructed using 66 microsatellite markers typed on either or both of two populations derived from inbred Dahl salt-sensitive (S) rats: F2(LEW x S) n = 151, and F2(WKY x S) n = 159. These populations had been raised on a high salt (8% NaCl) diet. Systolic blood pressure and heart weight were found to be genetically linked to two separate regions on rat chromosome 1 in the F2(LEW x S) population. One region was centered around the anonymous SA locus and accounted for 24 mmHg of blood pressure. The other region was 55 cM from the SA locus centered around a cluster of cytochromes P450 loci, and accounted for 30 mmHg of blood pressure. Since blood pressure and heart weight were highly correlated these same regions were also linked to heart weight. These results were cross-specific as linkage of these chromosome 1 regions to blood pressure and heart weight was not observed in several other F2 populations derived by crossing S and other normotensive control strains. This is presumably due to different alleles and/or different genetic backgrounds in the various populations. The SA region of chromosome 1 was found to influence body weight in F2(LEW x S) rats. Combining the present data with our previously published data on the F2(LEW x S) population showed that four separate quantitative trait loci with additive effects accounted for 106 mmHg and 38% of the total variance of blood pressure and for 506 mg and 34% of the total variance of heart wt.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp27Rathypertension  IDA  RGD 
Bp30Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp27Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp30Ratincreased systemic arterial blood pressure  IAGP  RGD 
Objects Annotated

QTLs
Bp27  (Blood pressure QTL 27)
Bp30  (Blood pressure QTL 30)

Strains
LEW  (Lewis)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D1M7Mit69 D1M7Mit69 Rattus norvegicus
Marker D1Mco2 D1Mco2 Rattus norvegicus
Marker D1Mco1 D1Mco1 Rattus norvegicus
Gene Acsm3 acyl-CoA synthetase medium-chain family member 3 Rattus norvegicus
Strain BN/SsNHsd null Rattus norvegicus
QTL Bp28 Blood pressure QTL 28 Rattus norvegicus
QTL Bp29 Blood pressure QTL 29 Rattus norvegicus
Gene Igf2 insulin-like growth factor 2 Rattus norvegicus
Strain LEW/NCrl null Rattus norvegicus
Strain MNS Milan normotensive strain Rattus norvegicus
Strain SR/Jr Salt Resistant Rattus norvegicus
Strain WKY null Rattus norvegicus
Strain WKY/NHsd null Rattus norvegicus

Additional Information