RGD Reference Report - Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. - Rat Genome Database

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Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13.

Authors: Zhang, QY  Dene, H  Deng, AY  Garrett, MR  Jacob, HJ  Rapp, JP 
Citation: Zhang QY, etal., Mamm Genome 1997 Sep;8(9):636-41
RGD ID: 61047
Pubmed: PMID:9271663   (View Abstract at PubMed)

The renin locus (Ren) on rat Chromosome (Chr) 13 had previously been shown to cosegregate with blood pressure in crosses involving Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. In the present work, interval mapping of blood pressure on Chr 13 with a large F2 (S x R), n = 233, population yielded a maximum LOD = 4.2 for linkage to blood pressure, but the quantitative trait locus (QTL) was only poorly localized to a large 35-centiMorgan (cM) segment of Chr 13. In the linkage analysis, the S-rat QTL allele (S) was associated with higher, and the R-rat QTL allele (R) with lower blood pressure, the difference between homozygotes being about 20 mm Hg. A congenic strain was made by introgressing the R-rat Ren allele into the recipient S strain. This congenic strain showed a 24 mm Hg reduction (P = 0.004) in blood pressure compared with S rats for rats fed 2% NaCl diet for 24 days; this difference was confirmed by two other independent tests. Two congenic substrains were derived from the first congenic strain with shorter R Chr 13 segments on the S background. Comparisons among these congenic strains showed that a blood pressure QTL was in the 24-cM chromosomal segment between Syt2 and D13M1Mit108. This segment does not include the renin locus, which is thus excluded from being the gene on rat Chr 13 responsible for genetic differences in blood pressure detected by linkage analysis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp159Rathypertension  IDA  RGD 
Bp25Rathypertension  IDA  RGD 
SS.SR-(D13Mit9-D13Mit1)/JrRatHypotension inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 

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Mammalian Phenotype


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Objects Annotated

QTLs
Bp159  (Blood pressure QTL 159)
Bp25  (Blood pressure QTL 25)

Strains
SR/Jr  (Salt Resistant)
SS.SR-(D13Mit9-D13Mit1)/Jr  (NA)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D13M1Mit108 D13M1Mit108 Rattus norvegicus
Strain BN BN Rattus norvegicus
Strain SS.SR-(D13N1-D13Mit1)/Jr null Rattus norvegicus
Strain SS.SR-(Syt2-D13Mit1)/Jr null Rattus norvegicus
Gene Syt2 synaptotagmin 2 Rattus norvegicus

Additional Information