RGD Reference Report - Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. - Rat Genome Database

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Effects of renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats.

Authors: St. Lezin, EM  Pravenec, M  Wong, AL  Liu, W  Wang, N  Lu, S  Jacob, HJ  Roman, RJ  Stec, DE  Wang, JM  Reid, IA  Kurtz, TW 
Citation: St. Lezin EM, etal., J Clin Invest 1996 Jan 15;97(2):522-7
RGD ID: 61046
Pubmed: (View Article at PubMed) PMID:8567976
DOI: Full-text: DOI:10.1172/JCI118444

To investigate whether a BP-regulatory locus exists in the vicinity of the renin locus on rat chromosome 13, we transferred this chromosome segment from the Dahl salt-sensitive (S) rat onto the genetic background of the Dahl salt-resistant (R) rat. In congenic Dahl R rats carrying the S renin gene and fed an 8% salt diet, systolic BP was significantly lower than in progenitor Dahl R rats: 127 +/- 1 mmHg versus 138 +/- 4 mmHg, respectively (P < 0.05). Moreover, the decreased BP in the congenic Dahl R strain was associated with decreased kidney renin mRNA and decreased plasma renin concentration. These findings demonstrate that the Dahl S strain carries alleles in or near the renin locus that confer lower plasma renin concentration and lower BP than the corresponding alleles in the Dahl R strain, at least when studied on the genetic background of the Dahl R rat and in the environment of a high salt diet. The occurrence of coincident reductions in kidney renin mRNA, plasma renin concentration, and BP after interstrain transfer of naturally occurring renin gene variants strongly suggests that genetically determined variation in renin gene expression can affect BP.

Annotation

Disease Annotations    
Hypotension  (IAGP)

Gene Ontology Annotations    

Biological Process

Phenotype Annotations    

Mammalian Phenotype
Phenotype Values via PhenoMiner

View PhenoMiner data from this reference here 

Objects Annotated

Genes (Rattus norvegicus)
Ren  (renin)

QTLs
Bp24  (Blood pressure QTL 24)

Objects referenced in this article
Marker D13Mit1 D13Mit1 Rattus norvegicus
QTL Bp25 Blood pressure QTL 25 Rattus norvegicus
Strain SR/Jr Salt Resistant Rattus norvegicus
Strain SS.SR-(D13Mit9-D13Mit1)/Jr null Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus

Additional Information