RGD Reference Report - Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. - Rat Genome Database

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Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats.

Authors: Garrett, MR  Dene, H  Walder, R  Zhang, QY  Cicila, GT  Assadnia, S  Deng, AY  Rapp, JP 
Citation: Garrett MR, etal., Genome Res 1998 Jul;8(7):711-23
RGD ID: 61040
Pubmed: PMID:9685318   (View Abstract at PubMed)

An F2 population (n = 151) derived from Dahl salt-sensitive (S) and Lewis rats was raised on a 8% NaCl diet for 9 weeks and analyzed for blood pressure quantitative trait loci (QTL) by use of a whole genome scan. Chromosomes 5 and 10 yielded lod scores for linkage to blood pressure that were significant; chromosomes 1, 2, 3, 8, 16, 17, and 18 gave lod scores suggestive for linkage. Chromosome 7 gave a significant signal for heart weight with a lesser effect on blood pressure. Congenic strains were constructed by introgressing Lewis low-blood-pressure QTL alleles for chromosomes 1, 5, 10, and 17 into the S genetic background. Congenic strains for chromosomes 1, 5, and 10 had significantly lower blood pressure than S, proving the existence of QTL on these chromosomes, but the chromosome 17 congenic strain failed to trap a contrasting QTL allele. The QTL allele increasing blood pressure originated from S rats for all QTL except those on chromosomes 2 and 7 in which the Lewis allele increased blood pressure. Interactions between each QTL and every other locus in the genome scan yielded significant interactions between chromosomes 10 and 4, and between chromosomes 2 and 3.



Disease Annotations    
hypertension  (IAGP,IDA)

Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Bp159  (Blood pressure QTL 159)
Bp168  (Blood pressure QTL 168)
Bp30  (Blood pressure QTL 30)
Bp36  (Blood pressure QTL 36)
Bp37  (Blood pressure QTL 37)
Bp38  (Blood pressure QTL 38)
Bp39  (Blood pressure QTL 39)
Bp40  (Blood pressure QTL 40)
Bp41  (Blood pressure QTL 41)
Bp7  (Blood pressure QTL 7)
Bp8  (Blood pressure QTL 8)

Strains
LEW  (Lewis)
LEW/NCrl  (NA)
SR/Jr  (Salt Resistant)
SS.LEW-(D10Mit10-D10Mgh1)/Jr  (NA)
SS.LEW-(D1Mco2-D1Mco35)/Jr  (NA)
SS.LEW-(D5Mit9-D5Mco10)/Jr  (NA)
SS/Jr  (Salt Sensitive)

Objects referenced in this article
Marker D17Mgh3 D17Mgh3 Rattus norvegicus
Marker D16Wox11 D16Wox11 Rattus norvegicus
Marker D18Mit1 D18Mit1 Rattus norvegicus
Marker D10Mit10 D10Mit10 Rattus norvegicus
Marker D7Mit5 D7Mit5 Rattus norvegicus
Marker D18Mit4 D18Mit4 Rattus norvegicus
Marker D5Mit9 D5Mit9 Rattus norvegicus
Marker D16Mit2 D16Mit2 Rattus norvegicus
Marker D2Mit1 D2Mit1 Rattus norvegicus
Marker D3Mgh6 D3Mgh6 Rattus norvegicus
Marker D7Mgh1 D7Mgh1 Rattus norvegicus
Marker D8Wox2 D8Wox2 Rattus norvegicus
Marker D10Wox6 D10Wox6 Rattus norvegicus
Marker D1M7Mit69 D1M7Mit69 Rattus norvegicus
Marker D1Mco2 D1Mco2 Rattus norvegicus
Marker D1Mco1 D1Mco1 Rattus norvegicus
Marker D2Mco19 D2Mco19 Rattus norvegicus
Marker D18Mco3 D18Mco3 Rattus norvegicus
Marker D5Mco10 D5Mco10 Rattus norvegicus
Marker D17Mco3 D17Mco3 Rattus norvegicus
Marker D17Mco10 D17Mco10 Rattus norvegicus
Marker D10Mco8 D10Mco8 Rattus norvegicus
Gene Acsm3 acyl-CoA synthetase medium-chain family member 3 Rattus norvegicus
Gene Agtr1b angiotensin II receptor, type 1b Rattus norvegicus
Strain BN/SsNHsd null Rattus norvegicus
QTL Bp12 Blood pressure QTL 12 Rattus norvegicus
QTL Bp26 Blood pressure QTL 26 Rattus norvegicus
QTL Bp27 Blood pressure QTL 27 Rattus norvegicus
QTL Bp35 Blood pressure QTL 35 Rattus norvegicus
Gene Edn2 endothelin 2 Rattus norvegicus
Gene Igf2 insulin-like growth factor 2 Rattus norvegicus
Strain MNS Milan normotensive strain Rattus norvegicus
Gene Nos2 nitric oxide synthase 2 Rattus norvegicus
Strain SS.LEW-(D17Mco3-D17Mco10)/Jr null Rattus norvegicus
Strain WKY null Rattus norvegicus
Strain WKY/NHsd null Rattus norvegicus

Additional Information