RGD Reference Report - Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. - Rat Genome Database

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Mapping of a quantitative trait locus for blood pressure on rat chromosome 2.

Authors: Deng, AY  Dene, H  Rapp, JP 
Citation: Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6
RGD ID: 61038
Pubmed: PMID:8040284   (View Abstract at PubMed)
PMCID: PMC296327   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI117341   (Journal Full-text)

A genetic map for rat chromosome 2 that includes five candidate genes for blood pressure regulation was constructed in a region containing a quantitative trait locus (QTL) for blood pressure. Two F2 populations of male rats raised on high salt (8% NaCI) diet from weaning were studied: F2(WKY x S), derived from a cross of Dahl salt-sensitive rats (S) and Wistar-Kyoto rats (WKY); and F2(MNS x S), derived from a cross of S rats and Milan normotensive strain (MNS). In both populations a blood pressure QTL was localized between Na+,K(+)-ATPase alpha 1 isoform and calmodulin-dependent protein kinase II-delta loci. The LOD score for existence of this blood pressure QTL based on the combined populations (n = 330) was 5.66 and accounted for 9.2% of the total variance and 26% of the genetic variance.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp158Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp158Ratincreased systemic arterial blood pressure  QTM  RGD 
Objects Annotated

QTLs
Bp10  (Blood pressure QTL 10)
Bp158  (Blood pressure QTL 158)

Strains
MNS  (Milan normotensive strain)
SS/Jr  (Salt Sensitive)
WKY  (NA)

Objects referenced in this article
Gene Agtr1b angiotensin II receptor, type 1b Rattus norvegicus
Gene Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 Rattus norvegicus
QTL Bp14 Blood pressure QTL 14 Rattus norvegicus
Gene Camk2d calcium/calmodulin-dependent protein kinase II delta Rattus norvegicus
Gene Fgg fibrinogen gamma chain Rattus norvegicus
Gene Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 Rattus norvegicus
Gene Mme membrane metallo-endopeptidase Rattus norvegicus
Gene Npr1 natriuretic peptide receptor 1 Rattus norvegicus
Gene Prlr prolactin receptor Rattus norvegicus

Additional Information