RGD Reference Report - Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. - Rat Genome Database

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Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

Authors: Deng, Y  Rapp, JP 
Citation: Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
RGD ID: 61037
Pubmed: (View Article at PubMed) PMID:1363813
DOI: Full-text: DOI:10.1038/ng0792-267

We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp11  (Blood pressure QTL 11)
Bp12  (Blood pressure QTL 12)

Objects referenced in this article
Marker D10Mit10 D10Mit10 Rattus norvegicus
Marker D10Wox6 D10Wox6 Rattus norvegicus
Marker D10Mco8 D10Mco8 Rattus norvegicus
Gene Ace angiotensin I converting enzyme Rattus norvegicus
Gene Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 Rattus norvegicus
QTL Bp10 Blood pressure QTL 10 Rattus norvegicus
QTL Bp158 Blood pressure QTL 158 Rattus norvegicus
QTL Bp25 Blood pressure QTL 25 Rattus norvegicus
QTL Bp36 Blood pressure QTL 36 Rattus norvegicus
QTL Bp9 Blood pressure QTL 9 Rattus norvegicus
Strain LEW Lewis Rattus norvegicus
Strain MNS Milan normotensive strain Rattus norvegicus
Gene Nos2 nitric oxide synthase 2 Rattus norvegicus
Gene Npr1 natriuretic peptide receptor 1 Rattus norvegicus
Strain SR/Jr Salt Resistant Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus
Strain WKY null Rattus norvegicus

Additional Information